Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They were initially named "just another kinase" 1 and 2 (since they were just two of many discoveries in a PCR-based screen of kinases),[1] but were ultimately published as "Janus kinase". The name is taken from the two-faced Roman god of beginnings, endings and duality, Janus, because the JAKs possess two near-identical phosphate-transferring domains. One domain exhibits the kinase activity, while the other negatively regulates the kinase activity of the first.
^Wilks (1989). "Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction". PNAS. 86 (5): 1603–7. Bibcode:1989PNAS...86.1603W. doi:10.1073/pnas.86.5.1603. PMC 286746. PMID 2466296.
Januskinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They...
A Januskinase inhibitor, also known as JAK inhibitor or jakinib, is a type of immune modulating medication, which inhibits the activity of one or more...
Januskinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Januskinase family and has been implicated in signaling...
Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the JAK3 gene. Januskinase 3 is a tyrosine kinase that belongs to the janus family...
them to escape their tumor and metastasize to other parts of the body. Januskinase 1 has been shown to interact with: ELP2, GNB2L1 IL6ST, Grb2, IL2RB, IRS1...
Januskinase 3 inhibitors, also called JAK3 inhibitors, are a new class of immunomodulatory agents that inhibit Januskinase 3. They are used for the treatment...
repigmentation differed from person to person. Current research suggests that the Januskinase/signal transducer and activator of transcription pathway (JAK/STAT pathway)...
infection It may also cause mild side effects such as headache and nausea. Januskinase (JAK) inhibitors are used to treat RA. Similar to biologic response modifiers...
interest-free bank Januskinase, a family of intracellular, nonreceptor tyrosine kinases including Januskinase 1 (JAK1) Januskinase 2 (JAK2) Januskinase 3 (JAK3)...
age. Chemically, it is a synthetic cyclohexylamino pyrrolopyrimidine januskinase inhibitor that is relatively selective for JAK1. It inhibits signal transduction...
arthritis, alopecia areata, and COVID-19. It acts as an inhibitor of januskinase (JAK), blocking the subtypes JAK1 and JAK2. Baricitinib is approved for...
alopecia areata (hair loss). Ritlecitinib is a kinase inhibitor which inhibits Januskinase 3 and tyrosine kinase. The most common side effects include headache...
cytokines including IL-4, IL-13 and IL-31 which activate downstream Januskinase (Jak) pathways. The active Jak pathways lead to inflammation and downstream...
kinase is Januskinase (JAK), many of whose effects are mediated by STAT proteins. (See JAK-STAT pathway.) Some kinases have dual-specificity kinase activities...
abnormalities in megakaryocytes; and The presence of a mutation in the Januskinase 2 (JAK2) gene. Patients usually have a very low level of erythropoietin...
steroid-refractory acute graft-versus-host disease. Ruxolitinib is a Januskinase inhibitor. It was developed and marketed by Incyte Corp in the US under...
course juvenile idiopathic arthritis, and ulcerative colitis. It is a januskinase (JAK) inhibitor, discovered and developed by the National Institutes...
spondyloarthritis. Upadacitinib is a Januskinase (JAK) inhibitor that works by blocking the action of enzymes called Januskinases. These enzymes are involved...
the U.S. Food and Drug Administration (FDA) authorized baricitinib, a Januskinase (JAK) inhibitor, for the treatment of severe alopecia areata. Ritlecitinib...
Januskinase and microtubule interacting protein 3 is a protein that in humans is encoded by the JAKMIP3 gene. GRCh38: Ensembl release 89: ENSG00000188385...
Deuruxolitinib (CTP-543) is a Januskinase inhibitor selective for JAK1 and JAK2. It is in development to treat alopecia areata. If approved the drug would...
site of treatment; folliculitis is also an occasional complication. Januskinase inhibitors, previously used in the treatment of cancer and other diseases...
anticancer medication used for the treatment of myelofibrosis. It is a Januskinase inhibitor and it is taken by mouth. The most common adverse reactions...
with Janus family kinases (JAKs) to affect intracellular signaling. Cytokines including interleukins, interferons and hemopoietins activate the Janus kinases...
medication used for the treatment of atopic dermatitis (eczema). It is a Januskinase inhibitor and it was developed by Pfizer. It is taken by mouth. The most...
cell surface. Upon binding IL-15β subunit activates Januskinase 1 (Jak1) and γc subunit Januskinase 3 (Jak3), which leads to phosphorylation and activation...
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