non-membrane spanning protein tyrosine kinase activity
Cellular component
cytoplasm
cytosol
membrane
extrinsic component of cytoplasmic side of plasma membrane
extracellular exosome
cytoskeleton
nucleus
Biological process
cell differentiation
intracellular signal transduction
phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
protein phosphorylation
regulation of type I interferon-mediated signaling pathway
regulation of cell population proliferation
type I interferon signaling pathway
peptidyl-tyrosine autophosphorylation
innate immune response
cell migration
interleukin-12-mediated signaling pathway
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
interleukin-23-mediated signaling pathway
interleukin-27-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7297
54721
Ensembl
ENSG00000105397
ENSMUSG00000032175
UniProt
P29597
Q9R117
RefSeq (mRNA)
NM_003331
NM_001205312 NM_018793
RefSeq (protein)
NP_003322
NP_001192241 NP_061263
Location (UCSC)
Chr 19: 10.35 – 10.38 Mb
Chr 9: 21.02 – 21.04 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene.[5][6]
TYK2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3).[7] It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling.
^ abcGRCh38: Ensembl release 89: ENSG00000105397 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032175 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Krolewski JJ, Lee R, Eddy R, Shows TB, Dalla-Favera R (March 1990). "Identification and chromosomal mapping of new human tyrosine kinase genes". Oncogene. 5 (3): 277–282. PMID 2156206.
^"Entrez Gene: TYK2 tyrosine kinase 2".
^Cite error: The named reference pmid9759489 was invoked but never defined (see the help page).
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