Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R).[5][6]
The distinguishing feature between janus kinase 2 and other JAK kinases is the lack of Src homology binding domains (SH2/SH3) and the presence of up to seven JAK homology domains (JH1-JH7). Nonetheless the terminal JH domains retain a high level of homology to tyrosine kinase domains. An interesting note is that only one of these carboxy-terminal JH domains retains full kinase function (JH1) while the other (JH2), previously thought to have no kinase functionality and accordingly termed a pseudokinase domain, has since been found to be catalytically active, albeit at only 10% that of the JH1 domain.[7][8]
Loss of Jak2 is lethal by embryonic day 12 in mice.[9]
JAK2 orthologs[10] have been identified in all mammals for which complete genome data are available.
^ abcGRCh38: Ensembl release 89: ENSG00000096968 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024789 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA (June 1998). "Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice". Endocrine Reviews. 19 (3): 225–68. doi:10.1210/edrv.19.3.0334. PMID 9626554.
^Brooks AJ, Dai W, O'Mara ML, Abankwa D, Chhabra Y, Pelekanos RA, et al. (2014). "Mechanism of activation of protein kinase JAK2 by the growth hormone receptor". Science. 344 (6185): 1249783. doi:10.1126/science.1249783. PMID 24833397. S2CID 27946074.
^Morgan KJ, Gilliland DG (2008). "A role for JAK2 mutations in myeloproliferative diseases". Annual Review of Medicine. 59 (1): 213–22. doi:10.1146/annurev.med.59.061506.154159. PMID 17919086.
^Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, Xu CF, Neubert TA, Skoda RC, Hubbard SR, Silvennoinen O (August 2011). "The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling". Nature Structural & Molecular Biology. 18 (9): 971–976. doi:10.1038/nsmb.2099. PMC 4504201. PMID 21841788.
^Neubauer H, Cumano A, Müller M, Wu H, Huffstadt U, Pfeffer K (May 1998). "Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis". Cell. 93 (3): 397–409. doi:10.1016/S0092-8674(00)81168-X. PMID 9590174. S2CID 11375232.
^"OrthoMaM phylogenetic marker: JAK2 coding sequence".[permanent dead link]
Januskinase2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Januskinase family and has been implicated in signaling...
the kinase activity of the first. The four JAK family members are: Januskinase 1 (JAK1) Januskinase2 (JAK2) Januskinase 3 (JAK3) Tyrosine kinase2 (TYK2)...
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them to escape their tumor and metastasize to other parts of the body. Januskinase 1 has been shown to interact with: ELP2, GNB2L1 IL6ST, Grb2, IL2RB, IRS1...
abnormalities in megakaryocytes; and The presence of a mutation in the Januskinase2 (JAK2) gene. Patients usually have a very low level of erythropoietin...
myelofibrosis. It is a macrocyclic protein kinase inhibitor. It mainly inhibits Januskinase2 (JAK2) and Fms-like tyrosine kinase 3\CD135 (FLT3). Common side effects...
interest-free bank Januskinase, a family of intracellular, nonreceptor tyrosine kinases including Januskinase 1 (JAK1) Januskinase2 (JAK2) Januskinase 3 (JAK3)...
capsules that are taken by mouth. It is a semi-selective inhibitor of Januskinase2 (JAK-2). It was approved by the FDA on 16 August 2019. Myelofibrosis is...
Receptor binding leads to recruitment of Januskinase2 and Tyrosine kinase2kinases. Januskinase2 and Tyrosine kinase2 transduce the signal and phosphorylate...
Examples of the P-type ATPase include Na+/K+-ATPase that is regulated by JanusKinase-2 as well as Ca2+ ATPase which exhibits sensitivity to ADP and ATP concentrations...
Deuruxolitinib (CTP-543) is a Januskinase inhibitor selective for JAK1 and JAK2. It is in development to treat alopecia areata. If approved the drug would...
polycythemia vera or primary thrombocytosis), most commonly due to a Januskinase2 (JAK2) gene mutation. Oral contraceptive use or pregnancy are other...
with hydroxyurea (a cytoreducing agent) or anagrelide (Agrylin). In Januskinase2 positive disorders, ruxolitinib (Jakafi) can be effective.[citation...
activity against cells expressing JAK2(V617F), a mutated form of the januskinase2 (JAK2) enzyme that is implicated in the pathophysiology of many myeloproliferative...
with Janus family kinases (JAKs) to affect intracellular signaling. Cytokines including interleukins, interferons and hemopoietins activate the Janus kinases...
Jak 2 can refer to: Jak II, the second installment in the Jak and Daxter video game series JAK2, member of the Januskinase family This disambiguation...
kinase is Januskinase (JAK), many of whose effects are mediated by STAT proteins. (See JAK-STAT pathway.) Some kinases have dual-specificity kinase activities...
anticancer medication used for the treatment of myelofibrosis. It is a Januskinase inhibitor and it is taken by mouth. The most common adverse reactions...
Januskinase and microtubule interacting protein 2 is a protein that in humans is encoded by the JAKMIP2 gene. The protein encoded by this gene is reported...
has been found on chromosome 22. YES1 has been shown to interact with Januskinase2, CTNND1, RPL10 and Occludin. GRCh38: Ensembl release 89: ENSG00000176105...
STAT5B has been shown to interact with: Glucocorticoid receptor, Januskinase 1, Januskinase2, and PTPN11. STAT5 GRCh38: Ensembl release 89: ENSG00000173757...
arthritis, alopecia areata, and COVID-19. It acts as an inhibitor of januskinase (JAK), blocking the subtypes JAK1 and JAK2. Baricitinib is approved for...
Growth hormone receptor has been shown to interact with SGTA, PTPN11, Januskinase2, Suppressor of cytokine signaling 1 and CISH. The GHR gene is used in...
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