positive regulation of defense response to virus by host
regulation of signaling receptor activity
interleukin-27-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
246778
246779
Ensembl
ENSG00000197272
ENSMUSG00000044701
UniProt
Q8NEV9
Q8K3I6
RefSeq (mRNA)
NM_145659
NM_145636
RefSeq (protein)
NP_663634
NP_663611
Location (UCSC)
Chr 16: 28.5 – 28.51 Mb
Chr 7: 126.19 – 126.19 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Interleukin 30 (IL-30) forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus it is also called IL27-p28. IL-27 is composed of α chain p28 and β chain Epstain-Barr induce gene-3 (EBI3). The p28 subunit, or IL-30, has an important role as a part of IL-27, but it can be secreted as a separate monomer and has its own functions in the absence of EBI3.[5][6] The discovery of IL-30 as individual cytokine is relatively new and thus its role in the modulation of the immune response is not fully understood.
^ abcGRCh38: Ensembl release 89: ENSG00000197272 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000044701 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, et al. (June 2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells". Immunity. 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
^Catalan-Dibene J, McIntyre LL, Zlotnik A (October 2018). "Interleukin 30 to Interleukin 40". Journal of Interferon & Cytokine Research. 38 (10): 423–439. doi:10.1089/jir.2018.0089. PMC 6206549. PMID 30328794.
Interleukin30 (IL-30) forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus it is also called IL27-p28. IL-27 is composed...
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