positive regulation of tyrosine phosphorylation of STAT protein
positive regulation of interferon-gamma production
negative regulation of interleukin-13 production
positive regulation of transcription, DNA-templated
positive regulation of immune response
defense response to virus
negative regulation of type 2 immune response
innate immune response
negative regulation of transcription, DNA-templated
positive regulation of MHC class I biosynthetic process
negative regulation of memory T cell differentiation
negative regulation of T cell differentiation
positive regulation of receptor signaling pathway via JAK-STAT
negative regulation of cell population proliferation
regulation of signaling receptor activity
cytokine-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
282618
330496
Ensembl
ENSG00000182393
ENSMUSG00000059128
UniProt
Q8IU54
Q4VK74
RefSeq (mRNA)
NM_172140
NM_001024673
RefSeq (protein)
NP_742152
NP_001019844
Location (UCSC)
Chr 19: 39.3 – 39.3 Mb
Chr 7: 28.21 – 28.21 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Interleukin-29 (IL-29) is a cytokine and it belongs to type III interferons group, also termed interferons λ (IFN-λ). IL-29 (alternative name IFNλ1) plays an important role in the immune response against pathogenes and especially against viruses by mechanisms similar to type I interferons, but targeting primarily cells of epithelial origin and hepatocytes.[5][6]
IL-29 is encoded by the IFNL1 gene located on chromosome 19 in humans.[5][7] It is a pseudogene in mice meaning the IL-29 protein is not produced in them.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000182393 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000059128 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcLazear HM, Nice TJ, Diamond MS (July 2015). "Interferon-λ: Immune Functions at Barrier Surfaces and Beyond". Immunity. 43 (1): 15–28. doi:10.1016/j.immuni.2015.07.001. PMC 4527169. PMID 26200010.
^Kelm NE, Zhu Z, Ding VA, Xiao H, Wakefield MR, Bai Q, Fang Y (October 2016). "The role of IL-29 in immunity and cancer". Critical Reviews in Oncology/Hematology. 106: 91–8. doi:10.1016/j.critrevonc.2016.08.002. PMC 7129698. PMID 27637354.
Interleukin-29 (IL-29) is a cytokine and it belongs to type III interferons group, also termed interferons λ (IFN-λ). IL-29 (alternative name IFNλ1) plays...
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes)...
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Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein that regulates the activities...
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Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit...
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Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. The protein encoded by...
Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene. IL-22 is an α-helical cytokine. IL-22 binds to a heterodimeric cell surface...
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2...
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with...
Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. Sometimes also called colony-stimulating factor...
the brand name Dupixent, is a monoclonal antibody blocking interleukin 4 and interleukin 13, used for allergic diseases such as atopic dermatitis (eczema)...
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