BMP8A, entrez:353500, bone morphogenetic protein 8a, OP-2
External IDs
MGI: 104515 HomoloGene: 135983 GeneCards: BMP8A
Gene location (Human)
Chr.
Chromosome 1 (human)[1]
Band
1p34.3
Start
39,491,636 bp[1]
End
39,529,869 bp[1]
Gene location (Mouse)
Chr.
Chromosome 4 (mouse)[2]
Band
4 D2.2|4 57.42 cM
Start
123,206,438 bp[2]
End
123,237,045 bp[2]
RNA expression pattern
Bgee
Human
Mouse (ortholog)
Top expressed in
right lobe of thyroid gland
left lobe of thyroid gland
periodontal fiber
tibia
islet of Langerhans
smooth muscle tissue
tibial nerve
right uterine tube
prefrontal cortex
thymus
Top expressed in
intestinal villus
calvaria
hair follicle
molar
jejunum
body of femur
ankle joint
lip
duodenum
morula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
transforming growth factor beta receptor binding
cytokine activity
BMP receptor binding
growth factor activity
Cellular component
extracellular region
extracellular space
Biological process
regulation of apoptotic process
multicellular organism development
positive regulation of pathway-restricted SMAD protein phosphorylation
cartilage development
negative regulation of insulin secretion
cell differentiation
regulation of MAPK cascade
SMAD protein signal transduction
cell development
BMP signaling pathway
ossification
diet induced thermogenesis
regulation of signaling receptor activity
energy homeostasis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
353500
12163
Ensembl
ENSG00000183682
ENSMUSG00000032726
UniProt
Q7Z5Y6
P34821
RefSeq (mRNA)
NM_181809
NM_001256019 NM_007558
RefSeq (protein)
NP_861525
NP_001242948 NP_031584
Location (UCSC)
Chr 1: 39.49 – 39.53 Mb
Chr 4: 123.21 – 123.24 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Bone morphogenetic protein 8A (BMP8A) is a protein that in humans is encoded by the BMP8A gene.[5]
BMP8A is a polypeptide member of the TGFβ superfamily of proteins. It, like other bone morphogenetic proteins (BMPs), is involved in the development of bone and cartilage. BMP8A may be involved in epithelial osteogenesis. It also plays a role in bone homeostasis. It is a disulfide-linked homodimer.
^ abcGRCh38: Ensembl release 89: ENSG00000183682 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032726 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: bone morphogenetic protein 8a".
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