positive regulation of endothelial cell differentiation
regulation of MAPK cascade
positive regulation of endothelial cell proliferation
SMAD protein signal transduction
positive regulation of aldosterone biosynthetic process
response to retinoic acid
ossification
kidney development
positive regulation of bone mineralization
positive regulation of epithelial cell proliferation
positive regulation of pathway-restricted SMAD protein phosphorylation
cellular response to BMP stimulus
response to magnesium ion
response to glucocorticoid
negative regulation of transcription by RNA polymerase II
endochondral ossification
response to activity
BMP signaling pathway
response to iron ion
positive regulation of lipopolysaccharide-mediated signaling pathway
multicellular organismal iron ion homeostasis
multicellular organism development
cellular response to mechanical stimulus
cartilage development
positive regulation of osteoblast differentiation
positive regulation of chondrocyte differentiation
osteoblast differentiation
immune response
positive regulation of neuron differentiation
positive regulation of protein secretion
inflammatory response
type B pancreatic cell development
positive regulation of transcription by RNA polymerase II
positive regulation of SMAD protein signal transduction
cellular iron ion homeostasis
regulation of signaling receptor activity
positive regulation of cell population proliferation
cell development
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
654
12161
Ensembl
ENSG00000153162
n/a
UniProt
P22004
P20722
RefSeq (mRNA)
NM_001718
NM_007556
RefSeq (protein)
NP_001709
NP_031582
Location (UCSC)
Chr 6: 7.73 – 7.88 Mb
n/a
PubMed search
[2]
[3]
Wikidata
View/Edit Human
View/Edit Mouse
Bone morphogenetic protein 6 is a protein that in humans is encoded by the BMP6 gene.[4][5][6]
The protein encoded by this gene is a member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.
As of April 2009, an additional function of BMP6 has been identified as described in Nature Genetics April; 41 [4]:386-8. BMP6 is the key regulator of hepcidin, the small peptide secreted by the liver which is the major regulator of iron metabolism in mammals.
[6]
^ abcGRCh38: Ensembl release 89: ENSG00000153162 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, et al. (Dec 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.
^Sauermann U, Meyermann R, Schluesener HJ (Jan 1993). "Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines". J Neurosci Res. 33 (1): 142–7. doi:10.1002/jnr.490330118. PMID 1453478. S2CID 35064968.
^ ab"Entrez Gene: BMP6 bone morphogenetic protein 6".
and 25 Related for: Bone morphogenetic protein 6 information
Bonemorphogeneticprotein6 is a protein that in humans is encoded by the BMP6 gene. The protein encoded by this gene is a member of the TGFβ superfamily...
Bonemorphogeneticproteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Originally discovered by their ability to...
Bonemorphogeneticprotein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. BMP-2 like other bonemorphogeneticproteins, plays an important role...
Bonemorphogeneticprotein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene. The protein...
Bonemorphogeneticprotein 8B is a protein that in humans is encoded by the BMP8B gene. The protein encoded by this gene is a member of the TGF-β superfamily...
Bonemorphogeneticprotein 5 is a protein that in humans is encoded by the BMP5 gene. The protein encoded by this gene is member of the TGFβ superfamily...
Bonemorphogeneticprotein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene. BMP10 is a polypeptide belonging to the TGF-β superfamily...
Bonemorphogeneticprotein 1, also known as BMP1, is a protein which in humans is encoded by the BMP1 gene. There are seven isoforms of the protein created...
Bonemorphogeneticprotein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene. The protein encoded by this gene is a...
The bonemorphogeneticprotein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been...
Bonemorphogeneticprotein 8A (BMP8A) is a protein that in humans is encoded by the BMP8A gene. BMP8A is a polypeptide member of the TGFβ superfamily of...
Bonemorphogeneticprotein 15 (BMP-15) is a protein that in humans is encoded by the BMP15 gene. It is involved in folliculogenesis, the process in which...
Bonemorphogeneticprotein receptor type-1B also known as CDw293 (cluster of differentiation w293) is a protein that in humans is encoded by the BMPR1B...
Bonemorphogeneticprotein receptor type II or BMPR2 is a serine/threonine receptor kinase encoded by the BMPR2 gene. It binds bonemorphogenetic proteins...
proper bone formation. Through the stimulation of growth factors such as transforming growth factor beta (TGF-B), bonemorphogeneticprotein6 (6-BMP-6), and...
component in the coupling of bone formation and its resorption during bone remodeling. Bonemorphogeneticproteins (BMPs) are proteins that are made of acidic...
tissue. When stimulating alveolar bone growth at the base of the crypt, expression of the bonemorphogeneticprotein-6 in the dental follicle may also be...
LDN193189 is a chemical compound used in the study of bonemorphogeneticprotein signalling through the ALK2, ALK3 and ALK6 receptors. It has been researched...
particularly expedient for the simulation of 3D cellular automatons. Bonemorphogeneticprotein Collective cell migration Embryonic development Pattern formation...
factor, and bonemorphogeneticproteins. Evidence suggests that bone cells produce growth factors for extracellular storage in the bone matrix. The release...
enzyme for bone repair during apoptosis (self-regulated cell death), resulting in lymphocytes containing excess bonemorphogeneticprotein 4 (BMP4) provided...
Global Information
