BMPR2 information

BMPR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HLQ, 3G2F
Identifiers
Aliases	BMPR2, BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK, bone morphogenetic protein receptor type 2
External IDs	OMIM: 600799 MGI: 1095407 HomoloGene: 929 GeneCards: BMPR2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	202,567,751 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	59,918,173 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; lower lobe of lung; ; urethra; ; parietal pleura; ; right lung; ; tibia; ; right ventricle; ; pons; ; middle temporal gyrus; ; spinal ganglia;
	Top expressed in
	cumulus cell; ; ciliary body; ; iris; ; carotid body; ; right lung lobe; ; substantia nigra; ; molar; ; retinal pigment epithelium; ; pineal gland; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane receptor protein serine/threonine kinase activity; ATP binding; protein serine/threonine kinase activity; activin receptor activity, type II; BMP binding; protein kinase activity; protein binding; kinase activity; growth factor binding; metal ion binding; nucleotide binding; transferase activity; BMP receptor activity; transforming growth factor beta-activated receptor activity; transforming growth factor beta receptor activity, type II; SMAD binding;
Cellular component	integral component of membrane; caveola; spanning component of plasma membrane; dendrite; neuronal cell body; membrane; cell surface; integral component of plasma membrane; plasma membrane; cytoplasm; basal plasma membrane; apical plasma membrane; extracellular space; nucleoplasm; postsynaptic density; receptor complex;
Biological process	endothelial cell apoptotic process; positive regulation of epithelial cell migration; transmembrane receptor protein serine/threonine kinase signaling pathway; negative regulation of vasoconstriction; positive regulation of endothelial cell proliferation; endochondral bone morphogenesis; positive regulation of endothelial cell migration; lymphangiogenesis; positive regulation of pathway-restricted SMAD protein phosphorylation; anterior/posterior pattern specification; regulation of cell population proliferation; lung alveolus development; negative regulation of cell growth; transcription by RNA polymerase II; regulation of lung blood pressure; protein phosphorylation; positive regulation of axon extension involved in axon guidance; artery development; blood vessel remodeling; BMP signaling pathway; mesoderm formation; vascular endothelial growth factor receptor signaling pathway; signal transduction; proteoglycan biosynthetic process; positive regulation of cartilage development; maternal placenta development; endothelial cell proliferation; cellular response to starvation; negative regulation of DNA biosynthetic process; chondrocyte development; negative regulation of systemic arterial blood pressure; positive regulation of osteoblast differentiation; retina vasculature development in camera-type eye; cellular response to BMP stimulus; phosphorylation; venous blood vessel development; brain development; retina development in camera-type eye; positive regulation of BMP signaling pathway; limb development; positive regulation of bone mineralization; negative regulation of chondrocyte proliferation; lymphatic endothelial cell differentiation; mitral valve morphogenesis; pharyngeal arch artery morphogenesis; tricuspid valve morphogenesis; outflow tract septum morphogenesis; atrioventricular valve morphogenesis; activin receptor signaling pathway; cardiac muscle tissue development; outflow tract morphogenesis; endocardial cushion development; negative regulation of cell proliferation involved in heart valve morphogenesis; positive regulation of ossification; positive regulation of transcription by RNA polymerase II; ventricular septum morphogenesis; atrial septum morphogenesis; semi-lunar valve development; transforming growth factor beta receptor signaling pathway; pattern specification process; aortic valve development; pulmonary valve development;
	Sources:Amigo / QuickGO
Orthologs
	659
	12168
	ENSG00000204217
	ENSMUSG00000067336
	Q13873
	O35607
	NM_001204; NM_033346
	NM_007561
	NP_001195
	NP_031587
	Wikidata
View/Edit Human	View/Edit Mouse

Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase encoded by the BMPR2 gene. It binds bone morphogenetic proteins, members of the TGF beta superfamily of ligands, which are involved in paracrine signaling. BMPs are involved in a host of cellular functions including osteogenesis, cell growth and cell differentiation. Signaling in the BMP pathway begins with the binding of a BMP to the type II receptor. This causes the recruitment of a BMP type I receptor, which the type II receptor phosphorylates. The type I receptor phosphorylates an R-SMAD, a transcriptional regulator.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000204217 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067336 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000204217 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067336 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

BMPR2 information

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