Bone morphogenetic protein 4 information

BMP4
Identifiers
Aliases	BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME, bone morphogenetic protein 4
External IDs	OMIM: 112262 MGI: 88180 HomoloGene: 7247 GeneCards: BMP4
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	46,628,126 bp
RNA expression pattern
	n/a
	Top expressed in
	meninges; ; semicircular canal; ; surface ectoderm; ; abdominal wall; ; posterior semicircular canal; ; amnion; ; calvaria; ; external carotid artery; ; anterior semicircular canal; ; vas deferens;
	More reference expression data
Gene ontology
Molecular function	heparin binding; cytokine activity; co-receptor binding; transforming growth factor beta receptor binding; growth factor activity; BMP receptor binding; protein binding; chemoattractant activity;
Cellular component	extracellular region; extracellular space; endoplasmic reticulum lumen;
Biological process	embryonic skeletal system morphogenesis; negative regulation of T cell differentiation in thymus; germ cell development; skeletal system development; mesenchymal cell differentiation involved in renal system development; cardiac septum development; ureteric bud development; positive regulation of protein phosphorylation; renal system process; positive regulation of endothelial cell differentiation; negative regulation of immature T cell proliferation in thymus; bud elongation involved in lung branching; tendon cell differentiation; anatomical structure formation involved in morphogenesis; ureter epithelial cell differentiation; negative regulation of cell cycle; mesenchymal to epithelial transition involved in metanephros morphogenesis; trachea development; post-embryonic development; monocyte differentiation; specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; BMP signaling pathway involved in renal system segmentation; cranial suture morphogenesis; mesonephros development; odontogenesis of dentin-containing tooth; telencephalon regionalization; negative regulation of chondrocyte differentiation; blood vessel development; negative regulation of mitotic nuclear division; angiogenesis; prostate gland morphogenesis; positive regulation of ERK1 and ERK2 cascade; smooth muscle tissue development; BMP signaling pathway involved in heart induction; negative regulation of epithelial cell proliferation; tissue development; metanephric collecting duct development; inner ear receptor cell differentiation; mesodermal cell fate determination; metanephros development; type B pancreatic cell development; regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of cell population proliferation; steroid hormone mediated signaling pathway; mammary gland formation; positive regulation of collagen biosynthetic process; renal system development; negative regulation of myoblast differentiation; cell fate commitment; common-partner SMAD protein phosphorylation; glomerular visceral epithelial cell development; SMAD protein signal transduction; ossification; kidney development; lung development; ureter smooth muscle cell differentiation; embryonic digit morphogenesis; epithelial-mesenchymal cell signaling; negative regulation of thymocyte apoptotic process; mesenchymal cell differentiation involved in kidney development; negative regulation of cell death; regulation of odontogenesis of dentin-containing tooth; BMP signaling pathway involved in ureter morphogenesis; mesenchymal cell proliferation involved in ureteric bud development; smooth muscle cell differentiation; lymphoid progenitor cell differentiation; epithelium development; positive regulation of transcription, DNA-templated; deltoid tuberosity development; negative regulation of prostatic bud formation; heart development; telencephalon development; branching involved in ureteric bud morphogenesis; positive regulation of kidney development; cartilage development; embryonic limb morphogenesis; negative regulation of MAP kinase activity; positive regulation of cartilage development; lens induction in camera-type eye; positive regulation of neuron differentiation; branching involved in prostate gland morphogenesis; regulation of protein import into nucleus; positive regulation of cell differentiation; erythrocyte differentiation; smoothened signaling pathway; camera-type eye development; secondary heart field specification; negative regulation of phosphorylation; regulation of smooth muscle cell differentiation; regulation of cell fate commitment; regulation of branching involved in prostate gland morphogenesis; cell differentiation; positive regulation of branching involved in lung morphogenesis; chondrocyte differentiation; regulation of cartilage development; organ induction; positive regulation of epithelial cell proliferation; epithelial cell proliferation involved in lung morphogenesis; negative regulation of cell proliferation involved in heart morphogenesis; negative regulation of apoptotic process; positive regulation of ossification; endochondral ossification; regulation of smooth muscle cell proliferation; regulation of morphogenesis of a branching structure; BMP signaling pathway; macrophage differentiation; negative regulation of metanephric comma-shaped body morphogenesis; embryonic skeletal system development; mesenchymal cell proliferation involved in ureter development; osteoblast differentiation; hematopoietic progenitor cell differentiation; positive regulation of BMP signaling pathway; regulation of gene expression; embryonic cranial skeleton morphogenesis; dorsal/ventral neural tube patterning; lung alveolus development; positive regulation of protein binding; anterior/posterior axis specification; negative regulation of transcription, DNA-templated; positive regulation of epidermal cell differentiation; branching morphogenesis of an epithelial tube; trachea formation; specification of animal organ position; negative regulation of glomerular mesangial cell proliferation; positive regulation of smooth muscle cell proliferation; intermediate mesodermal cell differentiation; pulmonary artery endothelial tube morphogenesis; pituitary gland development; positive regulation of cell death; lung morphogenesis; positive regulation of endothelial cell proliferation; bud dilation involved in lung branching; positive regulation of cardiac muscle fiber development; negative regulation of striated muscle tissue development; positive regulation of cell migration; negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway; BMP signaling pathway involved in nephric duct formation; positive regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of mesenchymal cell proliferation involved in ureter development; mesoderm formation; cellular response to growth factor stimulus; glomerular capillary formation; bronchus development; positive regulation of endothelial cell migration; multicellular organism development; negative regulation of metanephric S-shaped body morphogenesis; neural tube closure; vasculature development; embryonic morphogenesis; protein localization to nucleus; positive regulation of apoptotic process; embryonic skeletal joint morphogenesis; regulation of cell differentiation; negative regulation of branching involved in ureteric bud morphogenesis; mesodermal cell differentiation; neuron fate commitment; forebrain development; cloacal septation; bone development; camera-type eye morphogenesis; positive regulation of SMAD protein signal transduction; negative regulation of glomerulus development; embryonic hindlimb morphogenesis; positive chemotaxis; outflow tract morphogenesis; odontogenesis; negative regulation of transcription by RNA polymerase II; epithelial to mesenchymal transition involved in endocardial cushion formation; cardiac jelly development; cellular response to BMP stimulus; positive regulation of osteoblast differentiation; epithelial tube branching involved in lung morphogenesis; cardiac muscle cell differentiation; apoptotic process involved in endocardial cushion morphogenesis; muscular septum morphogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of bone mineralization; cardiac right ventricle morphogenesis; outflow tract septum morphogenesis; membranous septum morphogenesis; aortic valve morphogenesis; pulmonary valve morphogenesis; endocardial cushion development; endoderm development; coronary vasculature development; BMP signaling pathway involved in heart development; pharyngeal arch artery morphogenesis; positive regulation of cell proliferation involved in outflow tract morphogenesis; negative regulation of extrinsic apoptotic signaling pathway; regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of production of miRNAs involved in gene silencing by miRNA; post-translational protein modification; positive regulation of gene expression; positive regulation of epithelial to mesenchymal transition; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; regulation of signaling receptor activity; positive regulation of cell population proliferation; negative regulation of gene expression; negative regulation of pri-miRNA transcription by RNA polymerase II; regulation of apoptotic process; regulation of MAPK cascade; cell development; growth;
	Sources:Amigo / QuickGO
Orthologs
	652
	12159
	ENSG00000125378
	ENSMUSG00000021835
	P12644
	P21275
	NM_001202; NM_130850; NM_130851
	NM_007554; NM_001316360
NP_001193; NP_570911; NP_001334841; NP_001334842; NP_001334843;
	NP_001334844; NP_001334845; NP_001334846; NP_570912
	NP_001303289; NP_031580
	Wikidata
View/Edit Human	View/Edit Mouse

Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene.^[4]^[5] BMP4 is found on chromosome 14q22-q23.

BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. BMP4 is highly conserved evolutionarily. BMP4 is found in early embryonic development in the ventral marginal zone and in the eye, heart blood and otic vesicle.^[6]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021835 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ van den Wijngaard A, Weghuis DO, Boersma CJ, van Zoelen EJ, Geurts van Kessel A, Olijve W (November 1995). "Fine mapping of the human bone morphogenetic protein-4 gene (BMP4) to chromosome 14q22-q23 by in situ hybridization" (PDF). Genomics. 27 (3): 559–60. doi:10.1006/geno.1995.1096. hdl:2066/22049. PMID 7558046.
^ Oida S, Iimura T, Maruoka Y, Takeda K, Sasaki S (November 1995). "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library". DNA Seq. 5 (5): 273–5. doi:10.3109/10425179509030980. PMID 7579580.
^ Knöchel S, Dillinger K, Köster M, Knöchel W (November 2001). "Structure and expression of Xenopus tropicalis BMP-2 and BMP-4 genes". Mech. Dev. 109 (1): 79–82. doi:10.1016/S0925-4773(01)00506-8. PMID 11677055. S2CID 792305.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000021835 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7558046-4] van den Wijngaard A, Weghuis DO, Boersma CJ, van Zoelen EJ, Geurts van Kessel A, Olijve W (November 1995). "Fine mapping of the human bone morphogenetic protein-4 gene (BMP4) to chromosome 14q22-q23 by in situ hybridization" (PDF). Genomics. 27 (3): 559–60. doi:10.1006/geno.1995.1096. hdl:2066/22049. PMID 7558046.

[pmid7579580-5] Oida S, Iimura T, Maruoka Y, Takeda K, Sasaki S (November 1995). "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library". DNA Seq. 5 (5): 273–5. doi:10.3109/10425179509030980. PMID 7579580.

[pmid11677055-6] Knöchel S, Dillinger K, Köster M, Knöchel W (November 2001). "Structure and expression of Xenopus tropicalis BMP-2 and BMP-4 genes". Mech. Dev. 109 (1): 79–82. doi:10.1016/S0925-4773(01)00506-8. PMID 11677055. S2CID 792305.

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