Bone morphogenetic protein 7 information

BMP7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BMP, 1LX5, 1LXI, 1M4U
Identifiers
Aliases	BMP7, OP-1, bone morphogenetic protein 7
External IDs	OMIM: 112267 MGI: 103302 HomoloGene: 20410 GeneCards: BMP7
Gene location (Human)
Chr.	Chromosome 20 (human)
End	57,266,641 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	172,782,114 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; optic nerve; ; ganglionic eminence; ; olfactory bulb; ; thyroid gland; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; caudate nucleus; ; amygdala; ; internal globus pallidus;
	Top expressed in
	molar; ; allantois; ; lip; ; optic nerve; ; surface ectoderm; ; renal corpuscle; ; atrium; ; notochord; ; hair follicle; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	heparin binding; cytokine activity; transforming growth factor beta receptor binding; growth factor activity; BMP receptor binding; protein binding;
Cellular component	extracellular region; extracellular matrix; extracellular space; vesicle; collagen-containing extracellular matrix;
Biological process	eye development; pattern specification process; skeletal system development; ureteric bud development; negative regulation of neuron differentiation; embryonic pattern specification; mesenchyme development; anatomical structure formation involved in morphogenesis; negative regulation of cell cycle; mesonephros development; odontogenesis of dentin-containing tooth; mesenchymal cell differentiation; negative regulation of mitotic nuclear division; animal organ morphogenesis; metanephric mesenchyme morphogenesis; metanephros development; cellular response to hypoxia; regulation of pathway-restricted SMAD protein phosphorylation; regulation of removal of superoxide radicals; steroid hormone mediated signaling pathway; negative regulation of Notch signaling pathway; negative regulation of cell population proliferation; branching involved in salivary gland morphogenesis; regulation of apoptotic process; SMAD protein signal transduction; ossification; kidney development; negative regulation of cell death; tube morphogenesis; positive regulation of transcription, DNA-templated; negative regulation of prostatic bud formation; cartilage development; embryonic limb morphogenesis; negative regulation of MAP kinase activity; embryonic camera-type eye morphogenesis; positive regulation of neuron differentiation; positive regulation of cell differentiation; negative regulation of phosphorylation; regulation of branching involved in prostate gland morphogenesis; cell differentiation; neuron projection morphogenesis; nephrogenic mesenchyme morphogenesis; positive regulation of heterotypic cell-cell adhesion; epithelial cell differentiation; response to vitamin D; positive regulation of hyaluranon cable assembly; positive regulation of bone mineralization; dendrite development; negative regulation of neurogenesis; regulation of phosphorylation; BMP signaling pathway; positive regulation of osteoblast differentiation; epithelial to mesenchymal transition; negative regulation of transcription, DNA-templated; negative regulation of NF-kappaB transcription factor activity; branching morphogenesis of an epithelial tube; negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis; negative regulation of glomerular mesangial cell proliferation; response to estradiol; monocyte aggregation; metanephric mesenchymal cell proliferation involved in metanephros development; positive regulation of cell death; cell development; negative regulation of striated muscle cell apoptotic process; positive regulation of pathway-restricted SMAD protein phosphorylation; mesoderm formation; response to peptide hormone; cellular response to BMP stimulus; positive regulation of dendrite development; salivary gland morphogenesis; axon guidance; multicellular organism development; positive regulation of peptidyl-threonine phosphorylation; positive regulation of apoptotic process; protein localization to nucleus; embryonic skeletal joint morphogenesis; camera-type eye morphogenesis; positive regulation of transcription by RNA polymerase II; endocardial cushion formation; pericardium morphogenesis; neural fold elevation formation; hindbrain development; cardiac muscle tissue development; pharyngeal system development; cardiac septum morphogenesis; chorio-allantoic fusion; heart trabecula morphogenesis; allantois development; positive regulation of epithelial to mesenchymal transition; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; regulation of signaling receptor activity; positive regulation of gene expression; negative regulation of NIK/NF-kappaB signaling; regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	655
	12162
	ENSG00000101144
	ENSMUSG00000008999
	P18075
	P23359
	NM_001719
	NM_007557
	NP_001710; NP_001710.1
	NP_031583
	Wikidata
View/Edit Human	View/Edit Mouse

Bone morphogenetic protein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101144 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008999 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (November 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101144 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008999 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427904-5] Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (November 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.

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