positive regulation of epithelial cell proliferation
negative regulation of mononuclear cell migration
negative regulation of cortisol biosynthetic process
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of dendrite development
BMP signaling pathway
multicellular organism development
cartilage development
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of insulin-like growth factor receptor signaling pathway
type B pancreatic cell development
negative regulation of steroid biosynthetic process
negative regulation of epithelial to mesenchymal transition
positive regulation of transcription by RNA polymerase II
negative regulation of cell population proliferation
negative regulation of aldosterone biosynthetic process
endocardial cushion formation
pericardium morphogenesis
neural fold elevation formation
hindbrain development
cardiac muscle tissue development
pharyngeal system development
cardiac septum morphogenesis
chorio-allantoic fusion
heart trabecula morphogenesis
allantois development
regulation of signaling receptor activity
ear development
anterior head development
positive regulation of cell population proliferation
cell development
signal transduction
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
653
12160
Ensembl
ENSG00000112175
ENSMUSG00000032179
UniProt
P22003
P49003
RefSeq (mRNA)
NM_021073 NM_001329754 NM_001329756
NM_007555
RefSeq (protein)
NP_001316683 NP_001316685 NP_066551 NP_066551.1
NP_031581
Location (UCSC)
Chr 6: 55.75 – 55.88 Mb
Chr 9: 75.68 – 75.81 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Bone morphogenetic protein 5 is a protein that in humans is encoded by the BMP5 gene.[5][6][7]
The protein encoded by this gene is member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain cancers. Like other BMP's BMP5 is inhibited by chordin and noggin. It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver.
This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000112175 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032179 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Nov 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.
Bonemorphogeneticproteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Originally discovered by their ability to...
Bonemorphogeneticprotein5 is a protein that in humans is encoded by the BMP5 gene. The protein encoded by this gene is member of the TGFβ superfamily...
Bonemorphogeneticprotein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. BMP-2 like other bonemorphogeneticproteins, plays an important role...
Bonemorphogeneticprotein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene. The protein...
Bonemorphogeneticprotein 6 is a protein that in humans is encoded by the BMP6 gene. The protein encoded by this gene is a member of the TGFβ superfamily...
Bonemorphogeneticprotein 1, also known as BMP1, is a protein which in humans is encoded by the BMP1 gene. There are seven isoforms of the protein created...
Bonemorphogeneticprotein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene. BMP10 is a polypeptide belonging to the TGF-β superfamily...
Bonemorphogeneticprotein 8B is a protein that in humans is encoded by the BMP8B gene. The protein encoded by this gene is a member of the TGF-β superfamily...
Bonemorphogeneticprotein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene. The protein encoded by this gene is a...
Bonemorphogeneticprotein 8A (BMP8A) is a protein that in humans is encoded by the BMP8A gene. BMP8A is a polypeptide member of the TGFβ superfamily of...
Bonemorphogeneticprotein 15 (BMP-15) is a protein that in humans is encoded by the BMP15 gene. It is involved in folliculogenesis, the process in which...
Bonemorphogeneticprotein receptor type-1B also known as CDw293 (cluster of differentiation w293) is a protein that in humans is encoded by the BMPR1B...
The bonemorphogeneticprotein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been...
Bonemorphogeneticprotein receptor type II or BMPR2 is a serine/threonine receptor kinase encoded by the BMPR2 gene. It binds bonemorphogenetic proteins...
LDN193189 is a chemical compound used in the study of bonemorphogeneticprotein signalling through the ALK2, ALK3 and ALK6 receptors. It has been researched...
component in the coupling of bone formation and its resorption during bone remodeling. Bonemorphogeneticproteins (BMPs) are proteins that are made of acidic...
signals of bonemorphogeneticproteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a...
factor, and bonemorphogeneticproteins. Evidence suggests that bone cells produce growth factors for extracellular storage in the bone matrix. The release...
particularly expedient for the simulation of 3D cellular automatons. Bonemorphogeneticprotein Collective cell migration Embryonic development Pattern formation...
factor 5 is a protein that in humans is encoded by the GDF5 gene. The protein encoded by this gene is closely related to the bonemorphogeneticprotein (BMP)...
enzyme for bone repair during apoptosis (self-regulated cell death), resulting in lymphocytes containing excess bonemorphogeneticprotein 4 (BMP4) provided...
Global Information
