positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
positive regulation of transcription by RNA polymerase II
osteoblast fate commitment
negative regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4090
17129
Ensembl
ENSG00000113658
ENSMUSG00000021540
UniProt
Q99717
P97454
RefSeq (mRNA)
NM_005903 NM_001001419 NM_001001420
NM_001164041 NM_001164042 NM_008541
RefSeq (protein)
NP_001001419 NP_001001420 NP_005894
NP_001157513 NP_001157514 NP_032567
Location (UCSC)
Chr 5: 136.13 – 136.19 Mb
Chr 13: 56.85 – 56.89 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene.[5]
SMAD5, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic", based on a tradition of such unusual naming within the gene research community.[6] It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.
^ abcGRCh38: Ensembl release 89: ENSG00000113658 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021540 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135. S2CID 10124489.
^"Sonic Hedgehog, DICER, and the Problem With Naming Genes", Sep 26, 2014, Michael White. psmag.com
and 29 Related for: Mothers against decapentaplegic homolog 5 information
SMAD4, also called SMAD family member 4, Mothersagainstdecapentaplegichomolog 4, or DPC4 (Deleted in Pancreatic Cancer-4) is a highly conserved protein...
Mothersagainstdecapentaplegichomolog 9 also known as SMAD9, SMAD8, and MADH6 is a protein that in humans is encoded by the SMAD9 gene. SMAD9, as its...
Mothersagainstdecapentaplegichomolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. SMAD7 is a protein that, as its name describes...
in decapentaplegic fail to form these structures correctly, hence the name (decapenta-, fifteen, -plegic, paralysis). Dpp is the Drosophila homolog of...
been shown to interact with CDC27, Mothersagainstdecapentaplegichomolog 3 and Mothersagainstdecapentaplegichomolog 2. GRCh38: Ensembl release 89: ENSG00000164162...
PIAS4 has been shown to interact with Mothersagainstdecapentaplegichomolog 6, Mothersagainstdecapentaplegichomolog 7 and Lymphoid enhancer-binding factor...
has been shown to interact with Mothersagainstdecapentaplegichomolog 6 and Mothersagainstdecapentaplegichomolog 1. GRCh38: Ensembl release 89: ENSG00000037965...
cytokines and cyclins. The protein interacts with both mothersagainstdecapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This...
has been shown to interact with: AXIN1, DVL3, EPS8, and Mothersagainstdecapentaplegichomolog 3. Dishevelled GRCh38: Ensembl release 89: ENSG00000107404...
molecules including phosphatase and tensin homolog, E-cadherin, and mothersagainstdecapentaplegichomolog 4 (SMAD4). Through its effects on E-cadherin...
A mouse model carrying mutations in ApcΔ716 and Smad4 (mothersagainstdecapentaplegichomolog 4) is characterized with development of invasive adenocarcinomas...
Global Information
