positive regulation of pathway-restricted SMAD protein phosphorylation
BMP signaling pathway
multicellular organism development
cartilage development
osteoblast differentiation
regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
651
110075
Ensembl
ENSG00000152785
ENSMUSG00000029335
UniProt
P12645
Q8BHE5
RefSeq (mRNA)
NM_001201
NM_173404 NM_001310677
RefSeq (protein)
NP_001192
NP_001297606 NP_775580
Location (UCSC)
Chr 4: 81.03 – 81.06 Mb
Chr 5: 99 – 99.03 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene.[5]
The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, unlike other bone morphogenetic proteins (BMP's) inhibits the ability of other BMP's to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.
It is highly expressed in fractured tissues.
^ abcGRCh38: Ensembl release 89: ENSG00000152785 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029335 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)".
and 25 Related for: Bone morphogenetic protein 3 information
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particularly expedient for the simulation of 3D cellular automatons. Bonemorphogeneticprotein Collective cell migration Embryonic development Pattern formation...
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