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Volinanserin information


Volinanserin
Clinical data
Other namesMDL-100,907; M100907
ATC code
  • None
Identifiers
IUPAC name
  • (R)-(2,3-dimethoxyphenyl)-[1-[2-(4-fluorophenyl)ethyl]-4-piperidyl]methanol
CAS Number
  • 139290-65-6
PubChem CID
  • 5311271
IUPHAR/BPS
  • 185
ChemSpider
  • 4470782
UNII
  • EW71EE171J
ChEMBL
  • ChEMBL74355
CompTox Dashboard (EPA)
  • DTXSID6047363 Edit this at Wikidata
ECHA InfoCard100.123.797 Edit this at Wikidata
Chemical and physical data
FormulaC22H28FNO3
Molar mass373.468 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • c3cc(F)ccc3CCN(CC2)CCC2C(O)c(c1OC)cccc1OC

Volinanserin (INN) (developmental code name MDL-100,907) is a highly selective 5-HT2A receptor antagonist that is frequently used in scientific research to investigate the function of the 5-HT2A receptor.[1][2][3] It was also tested in clinical trials as a potential antipsychotic,[4][5] antidepressant,[6] and treatment for insomnia but was never marketed.[7]

  1. ^ Schmidt CJ, Fadayel GM, Sullivan CK, Taylor VL (November 1992). "5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine". European Journal of Pharmacology. 223 (1): 65–74. doi:10.1016/0014-2999(92)90819-P. PMID 1362159.
  2. ^ Herth MM, Kramer V, Piel M, Palner M, Riss PJ, Knudsen GM, Rösch F (April 2009). "Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET". Bioorganic & Medicinal Chemistry. 17 (8): 2989–3002. CiteSeerX 10.1.1.519.5663. doi:10.1016/j.bmc.2009.03.021. PMID 19329329.
  3. ^ Nic Dhonnchadha BA, Fox RG, Stutz SJ, Rice KC, Cunningham KA (April 2009). "Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model". Behavioral Neuroscience. 123 (2): 382–96. doi:10.1037/a0014592. PMC 3830454. PMID 19331461.
  4. ^ Offord SJ, Wong DF, Nyberg S (August 1999). "The role of positron emission tomography in the drug development of M100907, a putative antipsychotic with a novel mechanism of action". Journal of Clinical Pharmacology. 39 (S1): 17S–24S. doi:10.1002/j.1552-4604.1999.tb05933.x. PMID 10434243. S2CID 21311671.
  5. ^ Charney DS, Nestler PS, Sklar P, Buxbaum JD (July 2013). Neurobiology of Mental Illness. OUP USA. p. 767. ISBN 9780199934959.
  6. ^ Marek GJ, Martin-Ruiz R, Abo A, Artigas F (December 2005). "The selective 5-HT2A receptor antagonist M100907 enhances antidepressant-like behavioral effects of the SSRI fluoxetine". Neuropsychopharmacology. 30 (12): 2205–15. doi:10.1038/sj.npp.1300762. PMID 15886717.
  7. ^ Teegarden BR, Al Shamma H, Xiong Y (2008). "5-HT(2A) inverse-agonists for the treatment of insomnia". Current Topics in Medicinal Chemistry. 8 (11): 969–76. doi:10.2174/156802608784936700. PMID 18673166.

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Propranolol

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Vortioxetine

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Mescaline

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Trazodone

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Diphenhydramine

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Fluoxetine

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Tramadol

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Monoamine oxidase inhibitor

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Olanzapine

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Cyclobenzaprine

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Chlorpromazine

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Clozapine

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Bupropion

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Tricyclic antidepressant

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Ibogaine

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Psychedelic drug

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Serotonin

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Promethazine

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Haloperidol

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