Diphenhydramine (DPH) is an antihistamine and sedative mainly used to treat allergies, insomnia, and symptoms of the common cold. It is also less commonly used for tremors in parkinsonism, and nausea.[10] It is taken by mouth, injected into a vein, injected into a muscle, or applied to the skin.[10] Maximal effect is typically around two hours after a dose, and effects can last for up to seven hours.[10]
Common side effects include sleepiness, poor coordination and an upset stomach.[10] Its use is not recommended in young children or the elderly.[10][11] There is no clear risk of harm when used during pregnancy; however, use during breastfeeding is not recommended.[12] It is a first-generation H1-antihistamine and it works by blocking certain effects of histamine, which produces its antihistamine and sedative effects.[10][2] Diphenhydramine is also a potent anticholinergic, which means it also works as a deliriant at much higher than recommended doses as a result.[13] Its sedative and deliriant effects have led to some cases of recreational use.[14][2]
Diphenhydramine was first developed by George Rieveschl and came into commercial use in 1946.[15][16] It is available as a generic medication.[10] It is sold under the brand name Benadryl, among others.[10] In 2021, it was the 242nd most commonly prescribed medication in the United States, with more than 1million prescriptions.[17][18]
^Hubbard JR, Martin PR (2001). Substance Abuse in the Mentally and Physically Disabled. CRC Press. p. 26. ISBN 978-0-8247-4497-7.
^"Benylin Chesty Coughs (Original) - Summary of Product Characteristics (SmPC)". (emc). 24 February 2022. Archived from the original on 30 December 2022. Retrieved 29 December 2022.
^ abCite error: The named reference pmid2866055 was invoked but never defined (see the help page).
^Cite error: The named reference AHFS was invoked but never defined (see the help page).
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^Cite error: The named reference pmid19153052 was invoked but never defined (see the help page).
^"Showing Diphenhydramine (DB01075)". DrugBank. Archived from the original on 31 August 2009. Retrieved 5 September 2009.
^ abcdefgh"Diphenhydramine Hydrochloride". Drugs.com. American Society of Health-System Pharmacists. 6 September 2016. Archived from the original on 15 September 2016. Retrieved 28 September 2016.
^Schroeck JL, Ford J, Conway EL, Kurtzhalts KE, Gee ME, Vollmer KA, Mergenhagen KA (November 2016). "Review of Safety and Efficacy of Sleep Medicines in Older Adults". Clinical Therapeutics. 38 (11): 2340–2372. doi:10.1016/j.clinthera.2016.09.010. PMID 27751669.
^"Diphenhydramine Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 2 October 2016. Retrieved 28 September 2016.
^Ayd FJ (2000). Lexicon of Psychiatry, Neurology, and the Neurosciences. Lippincott Williams & Wilkins. p. 332. ISBN 978-0-7817-2468-5. Archived from the original on 8 September 2017.
^Cite error: The named reference Thomas2008 was invoked but never defined (see the help page).
^Dörwald FZ (2013). Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Functional Groups and Organic Compounds. John Wiley & Sons. p. 225. ISBN 978-3-527-64565-7. Archived from the original on 2 October 2016.
^"Benadryl". Ohio History Central. Archived from the original on 17 October 2016. Retrieved 28 September 2016.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Diphenhydramine - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Diphenhydramine (DPH) is an antihistamine and sedative mainly used to treat allergies, insomnia, and symptoms of the common cold. It is also less commonly...
sickness and nausea. Dimenhydrinate is a theoclate salt composed of diphenhydramine (an ethanolamine derivative) and 8-chlorotheophylline (a chlorinated...
varies in different countries, but which includes some combination of diphenhydramine, acrivastine, and/or cetirizine. It is sold by Kenvue and is used to...
consumption, excessive use and overdose of the antihistamine medicine diphenhydramine (commonly sold in the United States under the brand name Benadryl)...
ingredient diphenhydramine hydrochloride. It is sometimes repackaged by Navajo Manufacturing Co., Inc. using the label Handy Solutions. Diphenhydramine hydrochloride...
treatment for insomnia. The first-generation sedating antihistamines diphenhydramine, doxepin, doxylamine, and pyrilamine are the most widely used medications...
diphenhydramine has been criticised for a number of reasons, ranging from ethical to safety concerns, but also due to the risk of diphenhydramine’s paradoxical...
pill in a similar manner to other sedating antihistamines such as diphenhydramine. Pheniramine is also commonly found in eyedrops used for the treatment...
of the ethanolamine antihistamine class; it is closely related to diphenhydramine. It is a muscle relaxant that is used to treat muscle pain and to help...
containing scopolamine) as well as higher than recommended dosages of diphenhydramine (Benadryl). A number of plant deliriants such as that of the Solanaceae...
night. It consists of 500 milligrams of paracetamol, 25 milligrams of diphenhydramine hydrochloride (a sedating antihistamine) and other "non-hazardous ingredients"...
brand name Mandrax, which contained 250 mg methaqualone and 25 mg diphenhydramine within the same tablet, mostly in Europe. Commercial production of...
also known as diphenhydramine monoacefyllinate, is an anticholinergic used as an antiparkinsonian agent. It is a 1:1 salt of diphenhydramine with acefylline...
associated with sleep paralysis and the abuse of the antihistamine medicine diphenhydramine, commonly sold under the brand name Benadryl. He is typically described...
readily cross the blood–brain barrier; some of these drugs, such as diphenhydramine and doxylamine, may therefore be used to treat insomnia. H1-antihistamines...
comparing it to the benzodiazepine lorazepam and the antihistamine diphenhydramine, along with placebo, find that methocarbamol produces increased "liking"...
Allergin may refer to: Allergen Diphenhydramine, known by the trade name Allergin This disambiguation page lists articles associated with the title Allergin...
known to have caused akathisia in certain individuals. as well as diphenhydramine, trazodone, benzatropine, cyproheptadine, and beta blockers, particularly...
treatment for pain or cold/flu symptoms. Its active ingredient is: Diphenhydramine HCl 50 mg (antihistamine) Children's NyQuil is artificially flavored...
The degree of benefit is similar to other antihistamines such as diphenhydramine, which is a first-generation antihistamine. Common side effects include...
after it is caught. Treatment is generally with antihistamines such as diphenhydramine and ranitidine. Epinephrine may be used for severe symptoms. Along...
motion sickness combination drug dimenhydrinate (8-chlorotheophylline/diphenhydramine) is occasionally used in higher doses as a deliriant. The prescription...
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