"MAOI" redirects here. For the Easter Island statues, see Moai.
Monoamine oxidase inhibitor
Drug class
Ribbon diagram of human monoamine oxidase B, from PDB: 1GOS
Class identifiers
Synonyms
MAOI, RIMA
Use
Treatment of major depressive disorder, atypical depression, Parkinson's disease, and several other disorders
ATC code
N06AF
Mechanism of action
Enzyme inhibitor
Biological target
Monoamine oxidase enzymes: MAO-A and/or MAO-B
External links
MeSH
D008996
Legal status
In Wikidata
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). They are best known as effective antidepressants, especially for treatment-resistant depression and atypical depression.[1] They are also used to treat panic disorder, social anxiety disorder, Parkinson's disease, and several other disorders.
Reversible inhibitors of monoamine oxidase A (RIMAs) are a subclass of MAOIs that selectively and reversibly inhibit the MAO-A enzyme. RIMAs are used clinically in the treatment of depression and dysthymia. Due to their reversibility, they are safer in single-drug overdose than the older, irreversible MAOIs,[2] and weaker in increasing the monoamines important in depressive disorder.[3] RIMAs have not gained widespread market share in the United States.
How RIMAs work and why RIMAs can only minimally increase depression-related neurotransmitters
^Cristancho, Mario A. (20 November 2012). "Atypical Depression in the 21st Century: Diagnostic and Treatment Issues". Psychiatric Times. Archived from the original on 2 December 2013. Retrieved 23 November 2013.
^Isbister GK, et al. (2003). "Moclobemide poisoning: toxicokinetics and occurrence of serotonin toxicity". British Journal of Clinical Pharmacology. 56 (4): 441–450. doi:10.1046/j.1365-2125.2003.01895.x. PMC 1884375. PMID 12968990.
^"Neuroscience Education Institute > Activities > 2012CurbConsultPosted". www.neiglobal.com.
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