Aripiprazole, sold under the brand names Abilify and Aristada, among others, is an atypical antipsychotic.[7] It is primarily used in the treatment of schizophrenia and bipolar disorder;[7] other uses include as an add-on treatment in major depressive disorder and obsessive compulsive disorder (OCD), tic disorders, and irritability associated with autism.[7] Aripiprazole is taken by mouth or via injection into a muscle.[7] A Cochrane review found low-quality evidence of effectiveness in treating schizophrenia.[8]
In adults, side effects with greater than 10% incidence include weight gain, headache, akathisia, insomnia, and gastrointestinal effects like nausea and constipation, and lightheadedness and twitching which is common in antidepressants and antipsychotics.[4][5][6][9][10] Side effects in children are similar, and include sleepiness, increased appetite, and stuffy nose.[9] Common side effects include vomiting, constipation, sleepiness, dizziness, weight gain and movement disorders.[7] Serious side effects may include neuroleptic malignant syndrome, tardive dyskinesia and anaphylaxis.[7] It is not recommended for older people with dementia-related psychosis due to an increased risk of death.[7] In pregnancy, there is evidence of possible harm to the fetus.[7][11] It is not recommended in women who are breastfeeding.[7] It has not been very well studied in people less than 18 years old.[7]
Aripiprazole was approved for medical use in the United States in 2002.[7] It is available as a generic medication.[12] In 2021, it was the 99th most commonly prescribed medication in the United States, with more than 6million prescriptions.[13][14] It is on the World Health Organization's List of Essential Medicines.[15]
^"Aripiprazole Use During Pregnancy". Drugs.com. 22 August 2019. Retrieved 7 February 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^ abcdef"Abilify (aripiprazole) tablet Abilify (aripiprazole) solution Abilify Discmelt (aripiprazole) tablet, orally disintegrating Abilify (aripiprazole) injection, solution [Otsuka America Pharmaceutical, Inc.]". DailyMed. Otsuka America Pharmaceutical, Inc. April 2013. Retrieved 22 October 2013.
^ abcdef"Abilify Tablets, Orodispersible Tablets, Oral Solution – Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Otsuka Pharmaceuticals (UK) Ltd. 20 September 2013. Archived from the original on 4 March 2016. Retrieved 22 October 2013.
^ abcdef"ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS" (PDF). European Medicines Agency. Otsuka Pharmaceutical Europe Ltd. Archived from the original (PDF) on 23 October 2013. Retrieved 22 October 2013.
^ abcdefghijk"Aripiprazole, ARIPiprazole Lauroxil Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 26 February 2019.
^Belgamwar RB, El-Sayeh HG (August 2011). "Aripiprazole versus placebo for schizophrenia". The Cochrane Database of Systematic Reviews (8): CD006622. doi:10.1002/14651858.CD006622.pub2. PMID 21833956.
^ abCite error: The named reference Abilify was invoked but never defined (see the help page).
^"Abilify Discmelt, Abilify Maintena (aripiprazole) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 22 October 2013.
^"Prescribing medicines in pregnancy database". Australian Government. 3 March 2014. Retrieved 22 April 2014.
^British national formulary: BNF 76 (76th ed.). Pharmaceutical Press. 2018. p. 392. ISBN 978-0-85711-338-2.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Aripiprazole - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
^World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
Aripiprazole, sold under the brand names Abilify and Aristada, among others, is an atypical antipsychotic. It is primarily used in the treatment of schizophrenia...
Aripiprazole lauroxil, sold under the brand name Aristada, is a long-acting injectable atypical antipsychotic that was developed by Alkermes. It is an...
The rates of adverse effects of aripiprazole are: Weight gain Headache Agitation Insomnia Anxiety Nausea & vomiting Akathisia — a sense of unease and restlessness...
developed by Otsuka and Lundbeck, and is considered to be a successor to aripiprazole (Abilify). It was approved for medical use in the United States in July...
hyperactive muscle fibres thus reducing involuntary movement production. Aripiprazole is an FDA-approved antipsychotic drug that "acts as an antagonist at...
antipsychotic to an (or to a different) atypical antipsychotic, such as aripiprazole, ziprasidone, quetiapine, olanzapine, risperidone, or clozapine. These...
effects complicate the choice. In turn, risperidone, olanzapine, and aripiprazole have been recommended for the treatment of first-episode psychosis. The...
drug normalised to some extent the dopaminergic hyperactive state. Aripiprazole's mode of action differs from other atypical antipsychotics in its selectivity...
of schizophrenia, including avolition. According to a 2015 article, aripiprazole may be useful for treatment of apathy syndrome (avolition). However,...
hypotension and hyperprolactinemia. Aripiprazole binds D2 as a partial agonist but antagonizes D3. In addition, aripiprazole treats schizophrenia, bipolar disorder...
mania in bipolar disorder. Other recommended first-line treatments are aripiprazole, haloperidol, quetiapine, and risperidone. It is recommended in combination...
Antipsychotics are used to treat tics associated with Tourette syndrome. Aripiprazole, an atypical antipsychotic, is used as add-on medication to ameliorate...
treatments may also be useful; the atypical antipsychotics risperidone and aripiprazole are empirically validated for alleviating co-morbid irritability, though...
There is also a low incidence with thioridazine, clozapine, olanzapine, aripiprazole, and low doses of risperidone. Rabbit syndrome can be treated with anticholinergic...
paliperidone, aripiprazole, ziprasidone, risperidone and olanzapine; and produce weight gain similar to risperidone, clozapine and aripiprazole. They concluded...
medication aripiprazole, a partial agonist at D2 receptors, leading to tardive dyskinesia. As of 2013, reports of tardive dyskinesia in aripiprazole have grown...
classed as partial agonists at particular receptors include buspirone, aripiprazole, buprenorphine, nalmefene and norclozapine. Examples of ligands activating...
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