Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication.[6] Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychosis, and hallucinations from alcohol withdrawal.[6][7][8] It may be used by mouth or injection into a muscle or a vein.[6] Haloperidol typically works within 30 to 60 minutes.[6] A long-acting formulation may be used as an injection every four weeks by people with schizophrenia or related illnesses, who either forget or refuse to take the medication by mouth.[6]
Haloperidol may result in a movement disorder known as tardive dyskinesia which may be permanent.[6] Neuroleptic malignant syndrome and QT interval prolongation may occur, the latter particularly with IV administration.[6] In older people with psychosis due to dementia it results in an increased risk of death.[6] When taken during pregnancy it may result in problems in the infant.[6][9] It should not be used by people with Parkinson's disease.[6]
Haloperidol was discovered in 1958 by Paul Janssen,[10] prepared as part of a structure-activity relationship investigation into analogs of pethidine (meperidine).[11] It is on the World Health Organization's List of Essential Medicines.[12] It is the most commonly used typical antipsychotic.[13] In 2020, it was the 303rd most commonly prescribed medication in the United States, with more than 1million prescriptions.[14]
^ ab"Haloperidol Use During Pregnancy". Drugs.com. 10 February 2020. Retrieved 13 September 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^ abcdeCite error: The named reference PK1999 was invoked but never defined (see the help page).
^"Product Information Serenace" (PDF). TGA eBusiness Services. Aspen Pharma Pty Ltd. 29 September 2011. Archived from the original on 14 March 2017. Retrieved 29 May 2014.
^ abcdefghij"Haloperidol". The American Society of Health-System Pharmacists. Archived from the original on 2 January 2015. Retrieved 2 January 2015.
^Schuckit MA (November 2014). "Recognition and management of withdrawal delirium (delirium tremens)". The New England Journal of Medicine. 371 (22): 2109–2113. doi:10.1056/NEJMra1407298. PMID 25427113. S2CID 205116954.
^Plosker GL (July 2012). "Quetiapine: a pharmacoeconomic review of its use in bipolar disorder". PharmacoEconomics. 30 (7): 611–631. doi:10.2165/11208500-000000000-00000. PMID 22559293.
^"Prescribing medicines in pregnancy database". Australian Government. 3 March 2014. Archived from the original on 8 April 2014. Retrieved 2 January 2015.
^Sneader W (2005). Drug discovery : a history (Rev. and updated ed.). Chichester: Wiley. p. 124. ISBN 978-0-471-89979-2. Archived from the original on 8 December 2015.
^Ravina E (2011). The evolution of drug discovery: from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: Wiley-VCH. p. 62. ISBN 978-3-527-32669-3. Archived from the original on 8 December 2015.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
^Stevens A (2004). Health care needs assessment: the epidemiologically based needs assessment reviews (2nd ed.). Abingdon: Radcliffe Medical. p. 202. ISBN 978-1-85775-892-4. Archived from the original on 8 December 2015.
^"Haloperidol - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia...
Haloperidol decanoate, sold under the brand name Haldol Decanoate among others, is a typical antipsychotic which is used in the treatment of schizophrenia...
PMID 15825133. Axley, John (1972). "Rheumatic chorea controlled with haloperidol". The Journal of Pediatrics. 81 (6): 1216–7. doi:10.1016/S0022-3476(72)80272-5...
grouping of antipsychotics are the butyrophenones, an example of which is haloperidol. The newer, second-generation antipsychotics, also known as atypical...
effective or even more effective than the IM administration of haloperidol alone or haloperidol with lorazepam (which is the standard treatment of agitation...
seizures (when present). Typical antipsychotics such as phenothiazines and haloperidol have been used to control psychotic symptoms, but may produce many undesirable...
as an alternative to haloperidol when there is the need for rapid sedation of violent or agitated individuals, but haloperidol plus promethazine is preferred...
hallucinations. In severe cases, antipsychotics such as haloperidol can reduce or stop hallucinations. Haloperidol is effective against acute intoxication caused...
effective as ziprasidone and asenapine, and 12–16% less effective than haloperidol, quetiapine, and aripiprazole. A 2014 systematic review carried out by...
risk than atypicals, specifically first generation antipsychotics like haloperidol. Onset is often within a few weeks of starting the medication but can...
(medication). Furthermore, Kianush Sanjari indicated he was injected with haloperidol at Aminabad Psychiatric Hospital without diagnosis in 2019. Author Hengameh...
emergency because it can impair breathing. Older antipsychotics such as Haloperidol or Fluphenazine are more likely to cause acute dystonia than newer agents...
study in agitated elderly patients compared the effects of tiapride, haloperidol and placebo and found that while the two drugs had comparable efficacy...
Giannini, AJ; Eighan, MS; Loiselle, RH; Giannini, MC (1984). "Comparison of haloperidol and chlorpromazine in the treatment of phencyclidine psychosis". Journal...
akathisia-inducing drugs were allegedly used as a form of torture. Haloperidol, an antipsychotic medication, was used to induce intense restlessness...
can be caused by schizophrenia treatment with anti-psychotics, such as haloperidol, and by the anesthetic ketamine. Protein kinase A has been suggested...
elevated than the norm in people who stutter. The typical antipsychotic haloperidol has been the most used drug in treatment trials for stuttering. In double-blind...
antiemetics. Examples of butyrophenone-derived pharmaceuticals include: Haloperidol, the most widely used classical antipsychotic drug in this class Benperidol...
manage the sleep disturbance associated with condition. The antipsychotic haloperidol may also be used, as a major tranquilizer, in order to combat the overactivity...
Janssen Pharmaceutica.[citation needed] On 11 February 1958 he developed haloperidol, a major breakthrough in the treatment of schizophrenia. Working with...
tolerability and safety of adjunctive pimavanserin to risperidone and haloperidol were published in November 2012, and the results showed that pimavanserin...
approximately as effective as paliperidone, and slightly more effective than haloperidol, quetiapine, and aripiprazole. Common Tachycardia Hypotension Orthostatic...
Risperidone (atypical) has a similar rate of extrapyramidal symptoms to haloperidol (typical). A rare but potentially lethal condition of neuroleptic malignant...
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