Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder.[10] For schizophrenia, it can be used for both new-onset disease and long-term maintenance.[10] It is taken by mouth or by injection into a muscle.[10]
Common side effects include weight gain, movement disorders, dizziness, feeling tired, constipation, and dry mouth.[10] Other side effects include low blood pressure with standing, allergic reactions, neuroleptic malignant syndrome, high blood sugar, seizures, and tardive dyskinesia.[10] In older people with dementia, its use increases the risk of death.[10] Use in the later part of pregnancy may result in a movement disorder in the baby for some time after birth.[10] Although how it works is not entirely clear, it blocks dopamine and serotonin receptors.[10]
Olanzapine was patented in 1991 and approved for medical use in the United States in 1996.[10][11] It is available as a generic medication.[10] In 2021, it was the 164th most commonly prescribed medication in the United States, with more than 3million prescriptions.[12][13] Eli Lilly also markets olanzapine in a fixed-dose combination with fluoxetine as olanzapine/fluoxetine (Symbyax).[14] It is on the World Health Organization's List of Essential Medicines.[15]
^Cite error: The named reference Drugnames was invoked but never defined (see the help page).
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Anvisa (31 March 2023). "RDC Nº 784 – Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 – Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^"Zyprexa EPAR". European Medicines Agency. 27 September 1996. Retrieved 27 February 2024.
^Kassahun K, Mattiuz E, Nyhart E, Obermeyer B, Gillespie T, Murphy A, et al. (January 1997). "Disposition and biotransformation of the antipsychotic agent olanzapine in humans". Drug Metabolism and Disposition. 25 (1): 81–93. PMID 9010634.
^Mauri MC, Volonteri LS, Colasanti A, Fiorentini A, De Gaspari IF, Bareggi SR (2007). "Clinical pharmacokinetics of atypical antipsychotics: a critical review of the relationship between plasma concentrations and clinical response". Clinical Pharmacokinetics. 46 (5): 359–388. doi:10.2165/00003088-200746050-00001. PMID 17465637. S2CID 43859718.
^ abcCite error: The named reference TGA was invoked but never defined (see the help page).
^Cite error: The named reference MSR was invoked but never defined (see the help page).
^ abcdefghij"Olanzapine, Olanzapine Pamoate Monograph for Professionals". Drugs.com. AHFS. Retrieved 24 December 2018.
^Taylor D, Paton C, Kapur S (2015). The Maudsley Prescribing Guidelines in Psychiatry (12th ed.). London, U K: Wiley-Blackwell. p. 16. ISBN 978-1-118-75460-3.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Olanzapine – Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
^"FDA Approves Symbyax as First Medication for Treatment-Resistant Depression". Lilly. Eli Lilly. Retrieved 17 March 2021.
^World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. For...
adverse effects of the antipsychotic olanzapine, sorted by frequency of occurrence. Very common adverse effects of olanzapine, occurring more than 10%, include:...
names ALKS-33, RDC-0313) is an opioid antagonist that in the form of olanzapine/samidorphan (brand name Lybalvi) is used in the treatment of schizophrenia...
superior efficacy of olanzapine to the other drugs in terms of reduction in psychopathology and rate of hospitalizations, but olanzapine was associated with...
Amitriptyline/haloperidol Second-generation Venlafaxine/quetiapine Olanzapine/fluoxetine Olanzapine/sertraline There is insufficient evidence to determine if treatment...
olanzapine, and quetiapine) have also been found to possess efficacy in the treatment of bipolar depression as a monotherapy, whereas only olanzapine...
features of bipolar disorder asenapine was found be equally effective as olanzapine, but with a substantially superior side effect profile. In acute mania...
central core of pharmaceutical drugs including atypical antipsychotic olanzapine (Zyprexa) and antimuscarinic telenzepine. Thienobenzodiazepines act relatively...
Fluvoxamine may also elevate plasma levels of olanzapine by approximately two times. Combined olanzapine and fluvoxamine, which may cause increased sedation...
Lilly also markets fluoxetine in a fixed-dose combination with olanzapine as olanzapine/fluoxetine (Symbyax). Fluoxetine is frequently used to treat major...
(Latuda) – approved as an adjunct to mood stabilizer for bipolar depression Olanzapine (Zyprexa) – approved as an adjunct to antidepressant for major depression...
than olanzapine and risperidone; produce fewer movement related side effects than paliperidone, aripiprazole, ziprasidone, risperidone and olanzapine; and...
though evidence from the CATIE trials suggests it is less effective than olanzapine, and equally as effective compared to quetiapine. There are higher discontinuation...
schizophrenia. The mainstay of treatment is antipsychotic medication, including olanzapine and risperidone, along with counseling, job training and social rehabilitation...
greatest risk. However, various atypical antipsychotics such as clozapine, olanzapine, risperidone, quetiapine, and ziprasidone have also been implicated in...
for bipolar depression refractory to treatment with mood stabilizers. Olanzapine is effective in preventing relapses, although the supporting evidence...
indication for bipolar depression for fluoxetine/olanzapine combination from the FDA, and the indication of Olanzapine for acute mania and bipolar depression from...
efficacy in bipolar disorder (with the notable exceptions being quetiapine, olanzapine and possibly asenapine) as a monotherapy, even though the majority of...
Cymbalta (duloxetine) (2004), and its antipsychotic medication Zyprexa (olanzapine) (1996), although its primary revenue drivers are the diabetes drugs Humalog...
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