Trazodone, sold under many brand names,[1] is an antidepressant medication.[20] It is used to treat major depressive disorder, anxiety disorders, and insomnia.[20] The medication is taken orally.[20]
Common side effects include dry mouth, feeling faint, vomiting, and headache.[20] More serious side effects may include suicide, mania, irregular heart rate, and pathologically prolonged erections.[20] It is unclear if use during pregnancy or breastfeeding is safe.[21] It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor (SARI) class.[22][23] Trazodone also has sedating effects.[24]
Trazodone was approved for medical use in the United States in 1981.[20] It is available as a generic medication.[20] In 2021, it was the 22nd most commonly prescribed medication in the United States, with more than 26million prescriptions.[25][26]
^ ab"Trazodone". Drugs.com. Retrieved 9 February 2019.
^ abHubbard JR, Martin PR (2001). Substance Abuse in the Mentally and Physically Disabled. CRC Press. p. 26. ISBN 978-0-8247-4497-7.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^Cite error: The named reference Desyrel FDA label was invoked but never defined (see the help page).
^Cite error: The named reference Trazodone FDA label was invoked but never defined (see the help page).
^ abcTruven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013.
^"Trazodone". DrugBank. Retrieved 7 June 2015.
^Preskorn SH, Stanga CY, Feighner JP, Ross J (2012). Antidepressants: Past, Present and Future. Springer Science & Business Media. pp. 68–. ISBN 978-3-642-18500-7.
^"MicroMedex DrugPoints – Trazodone". Pharmacy Choice. Retrieved 20 April 2017.
^ abcCite error: The named reference pmid10379419 was invoked but never defined (see the help page).
^ abcdCite error: The named reference pmid22115401 was invoked but never defined (see the help page).
^ abCite error: The named reference pmid23192413 was invoked but never defined (see the help page).
^ abCite error: The named reference pmid20173086 was invoked but never defined (see the help page).
^Cite error: The named reference pmid26678742 was invoked but never defined (see the help page).
^Schatzberg AF, Nemeroff CB (2017). The American Psychiatric Association Publishing Textbook of Psychopharmacology (5th ed.). American Psychiatric Pub. pp. 460–. ISBN 978-1-58562-523-9.
^Cite error: The named reference pmid31379379 was invoked but never defined (see the help page).
^Cite error: The named reference pmid9836023 was invoked but never defined (see the help page).
^Lemke TL, Williams DA (2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. p. 615. ISBN 978-1-60913-345-0.
^ abcdefg"Trazodone". The American Society of Health-System Pharmacists. 17 March 2021. Retrieved 24 December 2021.
^"Trazodone Use During Pregnancy". Drugs.com. Retrieved 7 January 2018.
^Stahl SM (2008). Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. Cambridge University Press. p. 567. ISBN 978-0-521-85702-4.
^Lemke TL, Williams DA (2008). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. p. 586. ISBN 978-0-7817-6879-5.
^British national formulary: BNF 69 (69th ed.). British Medical Association. 2015. pp. 257–58. ISBN 978-0-85711-156-2.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Trazodone – Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Trazodone, sold under many brand names, is an antidepressant medication. It is used to treat major depressive disorder, anxiety disorders, and insomnia...
This is a list of adverse effects of the antidepressant trazodone, sorted by frequency of occurrence. Very common (>10% incidence) adverse effects include:...
visual snow, HPPD, prescription drugs, head trauma, or may be idiopathic. Trazodone, nefazodone, mirtazapine, topiramate, clomiphene, oral contraceptives...
longer marketed or was never marketed. It is a phenylpiperazine related to trazodone and nefazodone in chemical structure and is a serotonin antagonist and...
Lorpiprazole (Normarex) Mepiprazole (Psigodal) Nefazodone (Serzone, Nefadar) Trazodone (Desyrel) Vilazodone (Viibryd) – a related drug but does not fit into...
caused akathisia in certain individuals. as well as diphenhydramine, trazodone, benzatropine, cyproheptadine, and beta blockers, particularly propranolol...
iprindole, mianserin, mirtazapine, nefazodone, opipramol, tianeptine, and trazodone. The agents vilazodone and vortioxetine are partly atypical. Typical antidepressants...
symptoms of IBS in some patients. Similarly to other phenylpiperazines like trazodone, nefazodone, and etoperidone, mepiprazole produces mCPP as an active metabolite...
serotonin antagonist and reuptake inhibitor (SARI) in the same group as trazodone, nefazodone, and etoperidone. Acaprazine Enpiprazole Mepiprazole Tolpiprazole...
patient years. Nefazodone is a phenylpiperazine compound and is related to trazodone. It has been described as a serotonin antagonist and reuptake inhibitor...
structure includes a trazolopyridine-derived ring system. One example is trazodone. Other pharmaceutical drugs that contain a triazolopyridine ring system...
found to influence relapse rate. Studies have found that magnesium or trazodone can help treat the persisting withdrawal symptom of insomnia in recovering...
frequently than nimetazepam for this purpose. Antidepressants such as trazodone and mirtazapine or Z-drugs like zopiclone and zolpidem are first line...
interrogation that she and Thyrion also smoked methamphetamine, and injected Trazodone at the apartment after the friend left. The couple then returned to Thyrion's...
of the clitoris. Drugs may cause or affect clitoral priapism. The drug trazodone is known to cause male priapism as a side effect, but there is only one...
SARIs belong to the phenylpiperazine class of compounds. They include trazodone and nefazodone. The majority of the tricyclic antidepressants (TCAs) act...
and is chemically related to cariprazine, nefazodone, etoperidone, and trazodone. It is unusual in having twelve known crystalline polymorphs. Aripiprazole...
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