Vortioxetine, sold under the brand names Trintellix and Brintellix among others, is an antidepressant of the serotonin modulator and stimulator (SMS) class.[14][3] Its effectiveness is viewed as similar to that of other antidepressants.[14] It is taken by mouth.[14]
Common side effects include nausea, vomiting, constipation, and sexual dysfunction.[14][10] Serious side effects may include suicide in those under the age of 25, serotonin syndrome, bleeding, mania, and SIADH.[14] A withdrawal syndrome may occur if the medication is abruptly stopped or the dose is decreased.[14] Use during pregnancy and breastfeeding is not generally recommended.[15] Vortioxetine's mechanism of action is not entirely understood, but is believed to be related to increasing serotonin levels and possibly interacting with certain receptors for serotonin.[14][16][17]
It was approved for medical use in the United States in 2013.[14][18] In 2020, it was the 243rd most commonly prescribed medication in the United States, with more than 1million prescriptions.[19][20]
^"Updates to the Prescribing Medicines in Pregnancy database". Therapeutic Goods Administration (TGA). Australian Government. 12 May 2022. Retrieved 13 May 2022.
^ ab"Vortioxetine Tablet - Uses, Side Effects, and More". WebMD. Retrieved 13 April 2024.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^"Product Information Brintellix" (PDF). Therapeutic Goods Administration (TGA). Australian Government.
^"AusPAR: Vortioxetine hydrobromide". Therapeutic Goods Administration (TGA). Australian Government.
^"Prescription medicines: registration of new chemical entities in Australia, 2014". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^"Brintellix tablets 5, 10 and 20mg - Summary of Product Characteristics (SmPC)". (emc). 11 April 2022. Retrieved 19 December 2022.
^ abcCite error: The named reference Trintellix FDA label was invoked but never defined (see the help page).
^"Brintellix EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 15 January 2021.
^ abcdeCite error: The named reference pmid29189941 was invoked but never defined (see the help page).
^Bundgaard C, Pehrson AL, Sánchez C, Bang-Andersen B (2 January 2015). "Case Study 2". Blood-Brain Barrier in Drug Discovery. Hoboken, NJ: John Wiley & Sons, Inc. pp. 505–520. doi:10.1002/9781118788523.ch23. ISBN 9781118788523.
^ abcdefgh"Vortioxetine Hydrobromide Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 18 March 2019.
^British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 376. ISBN 9780857113382.
^Cite error: The named reference pmid25907797 was invoked but never defined (see the help page).
^Cite error: The named reference pmid25562777 was invoked but never defined (see the help page).
^Gibb A, Deeks ED (January 2014). "Vortioxetine: first global approval". Drugs. 74 (1): 135–145. doi:10.1007/s40265-013-0161-9. PMID 24311349. S2CID 5987668.
^"The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
^"Vortioxetine - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
Vortioxetine, sold under the brand names Trintellix and Brintellix among others, is an antidepressant of the serotonin modulator and stimulator (SMS) class...
describe the mechanism of action of the serotonergic antidepressant vortioxetine, which acts as a serotonin reuptake inhibitor (SRI), agonist of the 5-HT1A...
nefazodone, opipramol, tianeptine, and trazodone. The agents vilazodone and vortioxetine are partly atypical. Typical antidepressants include the SSRIs, SNRIs...
antagonist, acting solely as a 5-HT1A receptor partial agonist instead. Vortioxetine (Trintellix) – another closely related drug, could technically be considered...
and long in clinical trials in Japan. Takeda and Lundbeck submitted vortioxetine (Trintellix) to the Ministry of Health, Labour and Welfare in Japan....
less with atypical antidepressants like bupropion, agomelatine, and vortioxetine. Higher doses of antidepressants seem to be more likely to produce emotional...
tedatioxetine but was focused on another, more advanced Lundbeck drug candidate, vortioxetine. Tedatioxetine is reported to act as a triple reuptake inhibitor (serotonin...
anxiolytics, but also as antidepressants. The antidepressants vilazodone and vortioxetine are 5-HT1A receptor partial agonists. Flibanserin, a drug used for female...
(oxcarbazepine) – an anticonvulsant used as a mood stabilizer Trintellix (vortioxetine) – an antidepressant of the serotonin modulator and stimulator class...
less with atypical antidepressants like bupropion, agomelatine, and vortioxetine. Higher doses of antidepressants seem to be more likely to produce emotional...
Global Information
