clathrin-sculpted monoamine transport vesicle membrane
endoplasmic reticulum membrane
membrane
endoplasmic reticulum
cytoplasmic vesicle membrane
cytoplasmic vesicle
integral component of plasma membrane
cell junction
synaptic vesicle membrane
synapse
terminal bouton
Biological process
xenobiotic transmembrane transport
monoamine transport
neurotransmitter transport
aminergic neurotransmitter loading into synaptic vesicle
serotonin transport
transmembrane transport
serotonin uptake
xenobiotic transport
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6570
110877
Ensembl
ENSG00000036565
ENSMUSG00000036330
UniProt
P54219
Q8R090
RefSeq (mRNA)
NM_001135691 NM_001142324 NM_001142325 NM_003053
NM_153054
RefSeq (protein)
NP_001129163 NP_001135796 NP_001135797 NP_003044
NP_694694
Location (UCSC)
Chr 8: 20.14 – 20.18 Mb
Chr 8: 69.49 – 69.54 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Vesicular monoamine transporter 1 (VMAT1) also known as chromaffin granule amine transporter (CGAT) or solute carrier family 18 member 1 (SLC18A1) is a protein that in humans is encoded by the SLC18A1 gene. VMAT1 is an integral membrane protein, which is embedded in synaptic vesicles and serves to transfer monoamines, such as norepinephrine, epinephrine, dopamine, and serotonin, between the cytosol and synaptic vesicles.[5] SLC18A1 is an isoform of the vesicular monoamine transporter.
^ abcGRCh38: Ensembl release 89: ENSG00000036565 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000036330 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Eiden LE, Schäfer MK, Weihe E, Schütz B (February 2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflügers Arch. 447 (5): 636–40. doi:10.1007/s00424-003-1100-5. PMID 12827358. S2CID 20764857.
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solute carrier family 18 member 2 (SLC18A2) also known as vesicularmonoaminetransporter 2 (VMAT2) is a protein that in humans is encoded by the SLC18A2...
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