clathrin-sculpted acetylcholine transport vesicle membrane
AP-2 adaptor complex
AP-1 adaptor complex
clathrin-coated vesicle membrane
presynapse
membrane
terminal bouton
Biological process
neurotransmitter transport
neurotransmitter secretion
transmembrane transport
ammonium transmembrane transport
membrane organization
xenobiotic transmembrane transport
organic cation transport
acetate ester transport
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6572
20508
Ensembl
ENSG00000187714
ENSMUSG00000100241
UniProt
Q16572
O35304 Q3TYJ1
RefSeq (mRNA)
NM_003055
NM_021712
RefSeq (protein)
NP_003046
NP_068358
Location (UCSC)
Chr 10: 49.61 – 49.61 Mb
Chr 14: 32.18 – 32.19 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The Vesicular acetylcholine transporter (VAChT) is a neurotransmitter transporter which is responsible for loading acetylcholine (ACh) into secretory organelles in neurons making acetylcholine available for secretion.[5][6] It is encoded by Solute carrier family 18, member 3 (SLC18A3) gene, located within the first intron of the choline acetyltransferase gene. VAChT is able to transport ACh into vesicles by relying on an exchange between protons (H+) that were previously pumped into the vesicle diffusing out, thus acting as an antiporter. ACh molecules are then carried into the vesicle by the action of exiting protons.[7] Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase.
^ abcGRCh38: Ensembl release 89: ENSG00000187714 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000100241 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Erickson JD, Varoqui H (Dec 2000). "Molecular analysis of vesicular amine transporter function and targeting to secretory organelles". FASEB Journal. 14 (15): 2450–8. doi:10.1096/fj.00-0206rev. PMID 11099462. S2CID 15305436.
^Weihe E, Tao-Cheng JH, Schäfer MK, Erickson JD, Eiden LE (Apr 1996). "Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles". Proceedings of the National Academy of Sciences of the United States of America. 93 (8): 3547–52. Bibcode:1996PNAS...93.3547W. doi:10.1073/pnas.93.8.3547. PMC 39647. PMID 8622973.
^Waymire J. "Storage of ACh". University of Texas Medical Center.
and 28 Related for: Vesicular acetylcholine transporter information
The Vesicularacetylcholinetransporter (VAChT) is a neurotransmitter transporter which is responsible for loading acetylcholine (ACh) into secretory organelles...
(anticholinergic agents) are substances that block the action of the acetylcholine (ACh) neurotransmitter at synapses in the central and peripheral nervous...
solute carrier family 18 member 2 (SLC18A2) also known as vesicular monoamine transporter 2 (VMAT2) is a protein that in humans is encoded by the SLC18A2...
The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membranes of synaptic vesicles of presynaptic neurons. It transports...
do not affect the affinity of CTL1 and CTL2 to choline. Vesicularacetylcholinetransporter (VAChT) GRCh38: Ensembl release 89: ENSG00000115665 – Ensembl...
transporter 4 (ENT4) Vesicularacetylcholinetransporter (VAChT) Note that there is no plasmalemmal acetylcholinetransporter, as acetylcholine is terminated...
Acetylcholine (ACh) is an organic compound that functions in the brain and body of many types of animals (including humans) as a neurotransmitter. Its...
neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous...
vesicular monoamine transporter. The idea that there must be specific transport proteins associated with the uptake of monoamines and acetylcholine into...
action of acetylcholinesterase and therefore increases the levels of acetylcholine. Neostigmine was patented in 1931. It is on the World Health Organization's...
acetylcholinesterase, thus inhibiting hydrolysis of acetylcholine. This increases acetylcholine concentrations at cholinergic synapses. The precise mechanism...
and delayed gastric emptying. Because it enhances the transmission of acetylcholine signals in the brain and can cross the blood–brain barrier, physostigmine...
Characterization of unc-17 and unc-47, which encode the vesicularacetylcholinetransporter and vesicular GABA transporter have been described to date. 3. Docking The...
action of acetylcholinesterase and therefore increases the levels of acetylcholine. Pyridostigmine was patented in 1945 and came into medical use in 1955...
reversible inhibitors of the enzyme acetylcholinesterase. They resemble acetylcholine, but the carbamoylated enzyme undergoes the final hydrolysis step very...
Cholinergic agents are compounds which mimic the action of acetylcholine and/or butyrylcholine. In general, the word "choline" describes the various quaternary...
ATP-dependent transporters. They have high binding affinity for choline, transport it primarily to neurons and are indirectly associated with the acetylcholine production...
a prokinetic benzamide derivative. These drugs inhibit dopamine and acetylcholine esterase enzyme and have a gastrokinetic effect. Itopride is indicated...
interfere with either the production or reception of acetylcholine, or the hydrolysis of acetylcholine after it has achieved its function of neurotransmission;...
functions to deactivate the acetylcholine almost immediately by breaking it down. If the enzyme is inhibited, acetylcholine accumulates and nerve impulses...
acetylcholinesterase inhibitor. It prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase...
irreversibly deactivates the enzyme which leads to rapid build-up of acetylcholine at the synapse. Malathion is produced by the addition of dimethyl dithiophosphoric...
blocks acetylcholine from binding with muscarinic receptors, which reduces the pesticide's impact. However, atropine does not affect acetylcholine at nicotinic...
Bonner TI, Usdin TB (1994). "Functional identification of a vesicularacetylcholinetransporter and its expression from a "cholinergic" gene locus". J. Biol...
acetylcholinesterase (AChE), an enzyme that catalyzes the breakdown of acetylcholine, a neurotransmitter. Nerve agents are irreversible acetylcholinesterase...
adenosine A1 receptor, which enhances release of the neurotransmitter acetylcholine. Caffeine has a three-dimensional structure similar to that of adenosine...
Aldicarb is a cholinesterase inhibitor which prevents the breakdown of acetylcholine in the synapse. Aldicarb is considered "extremely hazardous" by the...
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