"VMAT" redirects here. For Volumetric modulated arc therapy, see Radiation therapy § Volumetric modulated arc therapy (VMAT).
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The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membranes of synaptic vesicles of presynaptic neurons. It transports monoamine neurotransmitters – such as dopamine, serotonin, norepinephrine, epinephrine, and histamine – into the vesicles, which release the neurotransmitters into synapses, as chemical messages to postsynaptic neurons. VMATs utilize a proton gradient generated by V-ATPases in vesicle membranes to power monoamine import.
Pharmaceutical drugs that target VMATs have possible applications for many conditions, leading to a plethora of biological research, including hypertension, drug addiction, psychiatric disorders, Parkinson's disease, and other neurological disorders. Many drugs that target VMATs act as inhibitors and alter the kinetics of the protein. Much research regarding the effects of altered VMATs on biological systems is still ongoing.
and 29 Related for: Vesicular monoamine transporter information
solute carrier family 18 member 2 (SLC18A2) also known as vesicularmonoaminetransporter 2 (VMAT2) is a protein that in humans is encoded by the SLC18A2...
The vesicularmonoaminetransporter (VMAT) is a transport protein integrated into the membranes of synaptic vesicles of presynaptic neurons. It transports...
Vesicularmonoaminetransporter 1 (VMAT1) also known as chromaffin granule amine transporter (CGAT) or solute carrier family 18 member 1 (SLC18A1) is a...
Monoaminetransporters (MATs) are proteins that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine...
amine-associated receptor 1 (TAAR1) and inhibiting vesicularmonoaminetransporter 2 (VMAT2) in monoamine neurons. To a lesser extent, it also acts as a neurotransmitter...
For example, certain proteins such as the dopamine transporter (DAT), vesicularmonoaminetransporter 2 (VMAT2), and dopamine receptors can be classified...
neuron, they may inhibit the reuptake of monoamine neurotransmitters through vesicularmonoaminetransporter 2 (VMAT2) and release the neurotransmitters...
that in humans is encoded by the SLC6A4 gene. SERT is a type of monoaminetransporter protein that transports the neurotransmitter serotonin from the...
is influenced by heredity and that a specific gene, called vesicularmonoaminetransporter 2 (VMAT2), predisposes humans towards spiritual or mystic experiences...
medication used to treat tardive dyskinesia. It acts as a vesicularmonoaminetransporter 2 (VMAT2) inhibitor. Valbenazine is used to treat tardive dyskinesia...
The plasma membrane monoaminetransporter (PMAT) is a low-affinity monoaminetransporter protein which in humans is encoded by the SLC29A4 gene. It is...
human dopamine neurons, as both compounds induce efflux from vesicularmonoaminetransporter 2 (VMAT2) and activate TAAR1 with comparable efficacy. Like...
by the solute carrier family 6 member 2 (SLC6A2) gene. NET is a monoaminetransporter and is responsible for the sodium-chloride (Na+/Cl−)-dependent reuptake...
Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose across the plasma membrane, a process known as facilitated...
Deutetrabenazine (trade name Austedo) is a vesicularmonoaminetransporter 2 inhibitor which is used for the treatment of chorea associated with Huntington's...
3 (SLC22A3) also known as the organic cation transporter 3 (OCT3) or extraneuronal monoaminetransporter (EMT) is a protein that in humans is encoded...
with human trace amine-associated receptor 1 (hTAAR1) and vesicularmonoaminetransporter 2 (VMAT2) in neurons. Dextroamphetamine is a more potent Central...
dopamine transporter or by the plasma membrane monoaminetransporter. Once back in the cytosol, dopamine can either be broken down by a monoamine oxidase...
glutamate transporters is composed of two primary subclasses: the excitatory amino acid transporter (EAAT) family and vesicular glutamate transporter (VGLUT)...
widely accepted model for monoaminetransporter function, sodium ions must bind to the extracellular domain of the transporter before dopamine can bind...
medications are used to treat tardive dyskinesia. These include the vesicularmonoaminetransporter 2 inhibitors tetrabenazine and deutetrabenazine. Extrapyramidal...
the synaptic cleft via monoaminetransporter-mediated release) by triggering reverse transport at vesicularmonoaminetransporters (specifically, VMAT1...
Dysdiadochokinesia has been linked to a mutation in SLC18A2, which encodes vesicularmonoaminetransporter 2 (VMAT2). "dysdiadochokinesia". Farlex Partner Medical Dictionary...
attenuates methamphetamine-induced changes in vesicularmonoaminetransporter 2 immunoreactivity and monoamine depletions in the striatum". The Journal of...
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