clathrin-sculpted monoamine transport vesicle membrane
membrane
plasma membrane
integral component of plasma membrane
cytoplasmic vesicle membrane
cytoplasmic vesicle
synaptic vesicle
dopaminergic synapse
synaptic vesicle membrane
terminal bouton
Biological process
locomotory behavior
response to amphetamine
post-embryonic development
serotonin transport
negative regulation of reactive oxygen species biosynthetic process
dopamine transport
neurotransmitter loading into synaptic vesicle
neurotransmitter transport
response to toxic substance
neurotransmitter secretion
sequestering of neurotransmitter
chemical synaptic transmission
monoamine transport
transmembrane transport
aminergic neurotransmitter loading into synaptic vesicle
serotonin uptake
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6571
214084
Ensembl
ENSG00000165646
ENSMUSG00000025094
UniProt
Q05940
Q8BRU6
RefSeq (mRNA)
NM_003054
NM_172523
RefSeq (protein)
NP_003045
NP_766111
Location (UCSC)
Chr 10: 117.24 – 117.28 Mb
Chr 19: 59.25 – 59.28 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Distribution of VMAT2 in the human brain.
The solute carrier family 18 member 2 (SLC18A2) also known as vesicular monoamine transporter 2 (VMAT2) is a protein that in humans is encoded by the SLC18A2 gene.[5] SLC18A2 is an integral membrane protein that transports monoamines—particularly neurotransmitters such as dopamine, norepinephrine, serotonin, and histamine—from cellular cytosol into synaptic vesicles.[6] In nigrostriatal pathway and mesolimbic pathway dopamine-releasing neurons, SLC18A2 function is also necessary for the vesicular release of the neurotransmitter GABA.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000165646 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025094 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Surratt CK, Persico AM, Yang XD, Edgar SR, Bird GS, Hawkins AL, Griffin CA, Li X, Jabs EW, Uhl GR (March 1993). "A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPs". FEBS Lett. 318 (3): 325–30. doi:10.1016/0014-5793(93)80539-7. PMID 8095030. S2CID 8062412.
^Eiden LE, Schäfer MK, Weihe E, Schütz B (February 2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflügers Arch. 447 (5): 636–40. doi:10.1007/s00424-003-1100-5. PMID 12827358. S2CID 20764857.
The vesicularmonoaminetransporter (VMAT) is a transport protein integrated into the membranes of synaptic vesicles of presynaptic neurons. It transports...
Monoaminetransporters (MATs) are proteins that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine...
Vesicularmonoaminetransporter 1 (VMAT1) also known as chromaffin granule amine transporter (CGAT) or solute carrier family 18 member 1 (SLC18A1) is a...
amine-associated receptor 1 (TAAR1) and inhibiting vesicularmonoaminetransporter2 (VMAT2) in monoamine neurons. To a lesser extent, it also acts as a neurotransmitter...
medication used to treat tardive dyskinesia. It acts as a vesicularmonoaminetransporter2 (VMAT2) inhibitor. Valbenazine is used to treat tardive dyskinesia...
is influenced by heredity and that a specific gene, called vesicularmonoaminetransporter2 (VMAT2), predisposes humans towards spiritual or mystic experiences...
For example, certain proteins such as the dopamine transporter (DAT), vesicularmonoaminetransporter2 (VMAT2), and dopamine receptors can be classified...
Deutetrabenazine (trade name Austedo) is a vesicularmonoaminetransporter2 inhibitor which is used for the treatment of chorea associated with Huntington's...
human dopamine neurons, as both compounds induce efflux from vesicularmonoaminetransporter2 (VMAT2) and activate TAAR1 with comparable efficacy. Like...
"Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicularmonoaminetransporter-2 function and methamphetamine-evoked dopamine release". Journal...
with human trace amine-associated receptor 1 (hTAAR1) and vesicularmonoaminetransporter2 (VMAT2) in neurons. Dextroamphetamine is a more potent Central...
neuron, they may inhibit the reuptake of monoamine neurotransmitters through vesicularmonoaminetransporter2 (VMAT2) and release the neurotransmitters...
medications are used to treat tardive dyskinesia. These include the vesicularmonoaminetransporter2 inhibitors tetrabenazine and deutetrabenazine. Extrapyramidal...
The plasma membrane monoaminetransporter (PMAT) is a low-affinity monoaminetransporter protein which in humans is encoded by the SLC29A4 gene. It is...
attenuates methamphetamine-induced changes in vesicularmonoaminetransporter2 immunoreactivity and monoamine depletions in the striatum". The Journal of...
Dysdiadochokinesia has been linked to a mutation in SLC18A2, which encodes vesicularmonoaminetransporter2 (VMAT2). "dysdiadochokinesia". Farlex Partner Medical Dictionary...
concentrations of the monoamine neurotransmitters and it releases these neurotransmitters from synaptic vesicles via vesicularmonoaminetransporter2. It also shares...
cytosolic dopamine (via vesicularmonoaminetransporter2 (VMAT2) and transport it to mitochondria where it is metabolized by monoamine oxidase. Excess dopamine...
by the solute carrier family 6 member 2 (SLC6A2) gene. NET is a monoaminetransporter and is responsible for the sodium-chloride (Na+/Cl−)-dependent reuptake...
that in humans is encoded by the SLC6A4 gene. SERT is a type of monoaminetransporter protein that transports the neurotransmitter serotonin from the...
widely accepted model for monoaminetransporter function, sodium ions must bind to the extracellular domain of the transporter before dopamine can bind...
Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene. The protein encoded by this gene is a vesicle-bound...
TAAR1 agonists and vesicularmonoaminetransporter2 inhibitors that can enter monoamine neurons; this allows them to release monoamine neurotransmitters...
Global Information
