positive regulation of multicellular organism growth
response to cAMP
lactation
response to ethanol
neurotransmitter transport
dopamine uptake
transmembrane transport
neurotransmitter uptake
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6531
13162
Ensembl
ENSG00000142319 ENSG00000276996
ENSMUSG00000021609
UniProt
Q01959
Q61327
RefSeq (mRNA)
NM_001044
NM_010020
RefSeq (protein)
NP_001035
NP_034150
Location (UCSC)
Chr 5: 1.39 – 1.45 Mb
Chr 13: 73.68 – 73.73 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The dopamine transporter (DAT, also sodium-dependent dopamine transporter) is a membrane-spanning protein coded for in the human by the SLC6A3 gene (also known as DAT1), that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dopamine into vesicles for storage and later release. Dopamine reuptake via DAT provides the primary mechanism through which dopamine is cleared from synapses, although there may be an exception in the prefrontal cortex, where evidence points to a possibly larger role of the norepinephrine transporter.[5]
DAT is implicated in a number of dopamine-related disorders, including attention deficit hyperactivity disorder, bipolar disorder, clinical depression, eating disorders, and substance use disorders. The gene that encodes the DAT protein is located on chromosome 5, consists of 15 coding exons, and is roughly 64 kbp long. Evidence for the associations between DAT and dopamine related disorders has come from a type of genetic polymorphism, known as a variable number tandem repeat, in the SLC6A3 gene, which influences the amount of protein expressed.[6]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021609 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Carboni E, Tanda GL, Frau R, Di Chiara G (September 1990). "Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals". Journal of Neurochemistry. 55 (3): 1067–70. doi:10.1111/j.1471-4159.1990.tb04599.x. PMID 2117046. S2CID 23682303.
^Vandenbergh DJ, Persico AM, Hawkins AL, Griffin CA, Li X, Jabs EW, Uhl GR (December 1992). "Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR". Genomics. 14 (4): 1104–6. doi:10.1016/S0888-7543(05)80138-7. PMID 1478653.
and 26 Related for: Dopamine transporter information
The dopaminetransporter (DAT, also sodium-dependent dopaminetransporter) is a membrane-spanning protein coded for in the human by the SLC6A3 gene (also...
by blocking the action of the dopaminetransporter (DAT). Reuptake inhibition is achieved when extracellular dopamine not absorbed by the postsynaptic...
mediated either by the dopaminetransporter or by the plasma membrane monoamine transporter. Once back in the cytosol, dopamine can either be broken down...
sodium/chloride-dependent family of neurotransmitter transporters, including dopamine, epinephrine, serotonin and GABA transporters. A single-nucleotide polymorphism (SNP)...
transport proteins for monoamines (i.e., the dopaminetransporter, norepinephrine transporter, and serotonin transporter) in monoamine neurons. Other SLC18A2...
three major classes are serotonin transporters (SERTs), dopaminetransporters (DATs), and norepinephrine transporters (NETs) and are responsible for the...
Dopaminetransporter deficiency syndrome (DTDS), also known as infantile parkinsonism-dystonia, is a rare movement disorder that causes progressively worsening...
binding site overlapping the substrate binding site. The Drosophila dopaminetransporter, which displays a pharmacology similar to SERT, was crystallized...
facilitate dopamine-related activity. For example, certain proteins such as the dopaminetransporter (DAT), vesicular monoamine transporter 2 (VMAT2),...
blocks the dopaminetransporter, inhibiting reuptake of dopamine from the synaptic cleft into the pre-synaptic axon terminal; the higher dopamine levels in...
uptake of dopamine (DA) by blocking dopaminetransporters (DAT). The dopaminetransporter controls the dynamics of the neurotransmitter dopamine. This neurotransmitter...
monoamine transporters, with pure SSRIs having strong affinity for the serotonin transporter and only weak affinity for the norepinephrine and dopamine transporters...
been associated with Rage syndrome. A genetic polymorphism in the dopaminetransporter gene has been linked to Rage syndrome, and dogs at risk of passing...
monoamine transporters when they are co-administered.[better source needed] Methylphenidate has both dopaminetransporter and norepinephrine transporter binding...
norepinephrine, and dopamine by blocking the action of one or more of the respective monoamine transporters (MATs), which include the serotonin transporter (SERT)...
membrane-bound monoamine transporters (i.e., the dopaminetransporter, norepinephrine transporter, or serotonin transporter) to either stop transporting...
synaptic dopamine through blocking the presynaptic dopaminetransporter. Another stimulant, amphetamine, reverses the dopaminetransporter and induces...
the transport direction of the dopaminetransporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT). When methamphetamine binds...
or reverses the transporter proteins for the monoamine neurotransmitters (namely the serotonin, norepinephrine and dopaminetransporters) either via trace...
medication. Cocaine blocks a dopaminetransporter responsible for the reuptake of dopamine. Without the transporter, dopamine diffuses much more slowly from...
be due to a ratio between the dopaminetransporter and VMAT2. Based on the understanding the increased cytosolic dopamine levels lead to dopaminergic cell...
may show reduced dopaminetransporter activity. A DLB diagnosis may be warranted if other conditions with reduced dopaminetransporter uptake can be ruled...
cellular monoamine transporter, especially the dopaminetransporter (DAT) and less so the norepinephrine (NET) and serotonin transporter. The mechanism of...
(dopamine receptor-interacting proteins) interactions. The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine...
by inhibiting the action of the serotonin transporter, norepinephrine transporter, and dopaminetransporter. These pharmacological properties make cocaethylene...
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