The norepinephrine transporter (NET), also known as noradrenaline transporter (NAT), is a protein that in humans is encoded by the solute carrier family 6 member 2 (SLC6A2) gene.[5]
NET is a monoamine transporter and is responsible for the sodium-chloride (Na+/Cl−)-dependent reuptake of extracellular norepinephrine (NE), which is also known as noradrenaline. NET can also reuptake extracellular dopamine (DA). The reuptake of these two neurotransmitters is essential in regulating concentrations in the synaptic cleft. NETs, along with the other monoamine transporters, are the targets of many antidepressants and recreational drugs. In addition, an overabundance of NET is associated with ADHD.[6][7] There is evidence that single-nucleotide polymorphisms in the NET gene (SLC6A2) may be an underlying factor in some of these disorders.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000103546 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000055368 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Pacholczyk T, Blakely RD, Amara SG (March 1991). "Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter". Nature. 350 (6316): 350–4. Bibcode:1991Natur.350..350P. doi:10.1038/350350a0. PMID 2008212. S2CID 4333895.
^Cite error: The named reference Schroeter was invoked but never defined (see the help page).
^ abTellioglu T, Robertson D (November 2001). "Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications". Expert Reviews in Molecular Medicine. 2001 (29): 1–10. doi:10.1017/S1462399401003878. PMID 14987367. S2CID 30965333.
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The norepinephrinetransporter (NET), also known as noradrenaline transporter (NAT), is a protein that in humans is encoded by the solute carrier family...
depression and attention-deficit hyperactivity disorder (ADHD). The norepinephrinetransporter (NET) serves as the fundamental mechanism for the inactivation...
neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrinetransporter (NET). This in turn...
three major classes are serotonin transporters (SERTs), dopamine transporters (DATs), and norepinephrinetransporters (NETs) and are responsible for the...
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and...
cortex, where evidence points to a possibly larger role of the norepinephrinetransporter. DAT is implicated in a number of dopamine-related disorders,...
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(MATs), which include the serotonin transporter (SERT), norepinephrinetransporter (NET), and dopamine transporter (DAT). This in turn results in an increase...
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significant association. Attempts to find a correlation between norepinephrinetransporter polymorphisms and depression have yielded negative results. One...
monoamine transporters when they are co-administered.[better source needed] Methylphenidate has both dopamine transporter and norepinephrinetransporter binding...
via plasma membrane transporters, such as the dopamine transporter (DAT), norepinephrinetransporter (NET), and serotonin transporter (SERT). Some, such...
has the highest selectivity for the serotonin transporter (SERT) compared to the norepinephrinetransporter (NET), making the side-effect profile relatively...
very selective for the dopamine transporter, with little to no effect on the norepinephrine and serotonin transporters 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl...
inhibits serotonin transporter (SERT) and norepinephrinetransporter (NET). It is metabolized to nortriptyline, a stronger norepinephrine reuptake inhibitor...
research, modafinil has little to no affinity for serotonin or norepinephrinetransporters and does not directly interact with these systems. However, studies...
membrane-bound monoamine transporters (i.e., the dopamine transporter, norepinephrinetransporter, or serotonin transporter) to either stop transporting...
serotonin transporter, norepinephrinetransporter, and dopamine transporter. These pharmacological properties make cocaethylene a serotonin-norepinephrine-dopamine...
in negative affective biases. It does not significantly affect norepinephrinetransporter (NET), serotonin, dopamine, adrenergic, histamine, acetylcholine...
proteins for monoamines (i.e., the dopamine transporter, norepinephrinetransporter, and serotonin transporter) in monoamine neurons. Other SLC18A2 inhibitors...
also blocks the serotonin transporter and norepinephrinetransporter, inhibiting reuptake of serotonin and norepinephrine from the synaptic cleft into...
Atomoxetine inhibits the presynaptic norepinephrinetransporter (NET), preventing the reuptake of norepinephrine throughout the brain along with inhibiting...
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