A monoamine reuptake inhibitor (MRI)[1] is a drug that acts as a reuptake inhibitor of one or more of the three major monoamine neurotransmitters serotonin, norepinephrine, and dopamine by blocking the action of one or more of the respective monoamine transporters (MATs), which include the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT). This in turn results in an increase in the synaptic concentrations of one or more of these neurotransmitters and therefore an increase in monoaminergic neurotransmission.
^Axel AM, Mikkelsen JD, Hansen HH (June 2010). "Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat". Neuropsychopharmacology. 35 (7): 1464–76. doi:10.1038/npp.2010.16. PMC 3055463. PMID 20200509.
and 25 Related for: Monoamine reuptake inhibitor information
A monoaminereuptakeinhibitor (MRI) is a drug that acts as a reuptakeinhibitor of one or more of the three major monoamine neurotransmitters serotonin...
A dopamine reuptakeinhibitor (DRI) is a class of drug which acts as a reuptakeinhibitor of the monoamine neurotransmitter dopamine by blocking the action...
reuptakeinhibitor (NRI, NERI) or noradrenaline reuptakeinhibitor or adrenergic reuptakeinhibitor (ARI), is a type of drug that acts as a reuptake inhibitor...
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A)...
Tesofensine (NS2330) is a serotonin–noradrenaline–dopamine reuptakeinhibitor from the phenyltropane family of drugs, which is being developed for the...
limiting its reabsorption (reuptake) into the presynaptic cell. They have varying degrees of selectivity for the other monoamine transporters, with pure...
(Nopron) – a drug related to this group but does not inhibit the reuptake of serotonin or the other monoamines. Medifoxamine (Clédial, Gerdaxyl) – could perhaps...
Methylphenidate targets DAT as a non-selective reuptakeinhibitor. Methylphenidate is not an inhibitor of SERT. It has been observed that the pathology...
TCA because, unlike other TCAs, it seems to be a fairly weak monoaminereuptakeinhibitor. Similarly to other TCAs, however, trimipramine does have antihistamine...
as a serotonin reuptakeinhibitor (Ki = 76 nM vs. 3 nM, respectively), but conversely, is more balanced as a monoaminereuptakeinhibitor (5-HT (Ki) = 76 nM;...
The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membranes of synaptic vesicles of presynaptic neurons. It transports...
inside the presynaptic neuron, they may inhibit the reuptake of monoamine neurotransmitters through vesicular monoamine transporter 2 (VMAT2) and release the...
19-005) is an antidepressive agent and non-selective monoamine transporter inhibitor that blocks the reuptake of dopamine, norepinephrine, and serotonin with...
member 2 (SLC6A2) gene. NET is a monoamine transporter and is responsible for the sodium-chloride (Na+/Cl−)-dependent reuptake of extracellular norepinephrine...
(kanna). It has been shown to act as a serotonin reuptakeinhibitor. Minocycline – microglia inhibitor and other actions; a 2018 systematic review and...
clinical trials. Selegiline Selegiline acts as a monoamine oxidase inhibitor, and increases levels of monoamine neurotransmitters in the brain. At doses under...
(Marplan, Marplon, Enerzer) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class used as an antidepressant. Along...
methylphenidate. Ethylphenidate acts as both a dopamine reuptakeinhibitor and norepinephrine reuptakeinhibitor, meaning it effectively boosts the levels of the...
them. Monoamine oxidases are well known enzymes in pharmacology, since they are the target for the action of a number of monoamine oxidase inhibitor drugs...
ketamine and the monoamine oxidase inhibitor (MAOI) tranylcypromine, which is of importance as the combination of a monoaminereuptakeinhibitor with an MAOI...
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