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Dopaminergic information


The chemical structure of the neurotransmitter dopamine

Dopaminergic means "related to dopamine" (literally, "working on dopamine"), dopamine being a common neurotransmitter.[1] Dopaminergic substances or actions increase dopamine-related activity in the brain. Dopaminergic brain pathways facilitate dopamine-related activity. For example, certain proteins such as the dopamine transporter (DAT), vesicular monoamine transporter 2 (VMAT2), and dopamine receptors can be classified as dopaminergic, and neurons that synthesize or contain dopamine and synapses with dopamine receptors in them may also be labeled as dopaminergic. Enzymes that regulate the biosynthesis or metabolism of dopamine such as aromatic L-amino acid decarboxylase or DOPA decarboxylase, monoamine oxidase (MAO), and catechol O-methyl transferase (COMT) may be referred to as dopaminergic as well. Also, any endogenous or exogenous chemical substance that acts to affect dopamine receptors or dopamine release through indirect actions (for example, on neurons that synapse onto neurons that release dopamine or express dopamine receptors) can also be said to have dopaminergic effects, two prominent examples being opioids, which enhance dopamine release indirectly in the reward pathways, and some substituted amphetamines, which enhance dopamine release directly by binding to and inhibiting VMAT2.

  1. ^ Melinosky C (27 November 2022). "Parkinson's Disease: Glossary of Terms". WebMD.

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Dopaminergic

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Look up dopaminergic in Wiktionary, the free dictionary. Dopaminergic means "related to dopamine" (literally, "working on dopamine"), dopamine being a...

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Dopamine

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hyperactivity disorder (ADHD) are associated with decreased dopamine activity. Dopaminergic stimulants can be addictive in high doses, but some are used at lower...

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Dopaminergic pathways

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Dopaminergic pathways (dopamine pathways, dopaminergic projections) in the human brain are involved in both physiological and behavioral processes including...

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Dopaminergic cell groups

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Dopaminergic cell groups, DA cell groups, or dopaminergic nuclei are collections of neurons in the central nervous system that synthesize the neurotransmitter...

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Ghrelin

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function in energy homeostasis, ghrelin also activates the cholinergic–dopaminergic reward link in inputs to the ventral tegmental area and in the mesolimbic...

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Substantia nigra

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high levels of neuromelanin in dopaminergic neurons. Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra...

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Nigrostriatal pathway

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The nigrostriatal pathway is a bilateral dopaminergic pathway in the brain that connects the substantia nigra pars compacta (SNc) in the midbrain with...

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Dopamine antagonist

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A dopamine antagonist, also known as an anti-dopaminergic and a dopamine receptor antagonist (DRA), is a type of drug which blocks dopamine receptors by...

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Mesolimbic pathway

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mesolimbic pathway, sometimes referred to as the reward pathway, is a dopaminergic pathway in the brain. The pathway connects the ventral tegmental area...

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List of dopaminergic drugs

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This is a list of dopaminergic drugs. These are pharmaceutical drugs, naturally occurring compounds and other chemicals that influence the function of...

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Dopamine receptor

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of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus...

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Hypokinesia

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uncomfortable sleeping experience even after dopaminergic treatments. Once the reaction to dopaminergic drugs begins to fluctuate in Parkinson's patients...

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Dopamine agonist

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environmental triggers have been linked to the disease. In Parkinson's disease dopaminergic neurons that produce the neurotransmitter dopamine in the brain slowly...

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Sympathomimetic drug

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receptor), such as α-adrenergic agonists, β-adrenergic agonists, and dopaminergic agonists; or indirect-acting (interaction not between drug and receptor)...

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Dopamine reuptake inhibitor

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susceptibility to addictive behavior given increase in dopaminergic neurotransmission.[citation needed] The dopaminergic pathways are considered to be strong reward...

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Ventral tegmental area

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the midline on the floor of the midbrain. The VTA is the origin of the dopaminergic cell bodies of the mesocorticolimbic dopamine system and other dopamine...

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Amphetamine

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release of dopamine in the central nervous system. Amphetamine and other dopaminergic drugs also increase power output at fixed levels of perceived exertion...

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AAQ

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IATA code AAQ Eastern Abenaki language, ISO 939-3 language code aaq Dopaminergic cell group Aaq the Swiss Agency of Accreditation and Quality Assurance...

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Punding

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Parkinson's disease, but mainly in cases of patients being treated with dopaminergic drugs. It has also been described in methamphetamine and cocaine users...

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Pars compacta

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reticulata); it is situated medial to the pars reticulata. It is formed by dopaminergic neurons. It projects to the striatum and portions of the cerebral cortex...

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Reward system

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dopaminergic terminals of this region. Nicotinic receptors localize to dopaminergic cell bodies and local nicotine injections increase dopaminergic cell...

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Neurotoxicity

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(DOPAL), is a potent inducer of programmed cell death (apoptosis) in dopaminergic neurons. DOPAL may play an important role in the pathology of Parkinson's...

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Retracted article on dopaminergic neurotoxicity of MDMA

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"Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy")", is an article by George A. Ricaurte that...

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Extrapyramidal symptoms

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5-HT2A receptor affinity which lead to lower rates of EPS. Other anti-dopaminergic drugs, like the antiemetic metoclopramide, can also result in extrapyramidal...

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Neuroleptic malignant syndrome

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other drugs with anti-dopaminergic activity, such as the antiemetic metoclopramide, can induce NMS. Tetracyclics with anti-dopaminergic activity have been...

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Ultradian rhythm

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lasting approximately 4 hours were attributed to the dopaminergic system in mammals. When the dopaminergic system is perturbed either by use of drugs or by...

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