Serotonin transporter information

SLC6A4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5I6X, 5I73, 5I75, 5I6Z, 5I71, 5I74
Identifiers
Aliases	SLC6A4, 5-HTT, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, Solute Carrier Family 6 (neurotransmitter transporter), member 4, solute carrier family 6 member 4, 5-HTTLPR
External IDs	OMIM: 182138 MGI: 96285 HomoloGene: 817 GeneCards: SLC6A4
Gene location (Human)
Chr.	Chromosome 17 (human)
End	30,236,002 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	76,923,166 bp
RNA expression pattern
	Top expressed in
	right lung; ; jejunal mucosa; ; lower lobe of lung; ; placenta; ; upper lobe of left lung; ; duodenum; ; superior vestibular nucleus; ; oral cavity; ; islet of Langerhans; ; monocyte;
	Top expressed in
	dorsal tegmental nucleus; ; blood; ; jejunum; ; yolk sac; ; duodenum; ; set of raphe nuclei of tegmentum of midbrain; ; adrenal gland; ; intestinal villus; ; secondary oocyte; ; dorsal raphe nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cocaine binding; nitric-oxide synthase binding; protein homodimerization activity; myosin binding; syntaxin-1 binding; metal ion binding; neurotransmitter:sodium symporter activity; actin filament binding; monoamine transmembrane transporter activity; protein binding; symporter activity; serotonin:sodium symporter activity; dopamine:sodium symporter activity; serotonin binding;
Cellular component	integral component of membrane; cytosol; endosome; membrane; integral component of plasma membrane; membrane raft; neuron projection; endosome membrane; endomembrane system; presynapse; plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; serotonergic synapse; focal adhesion; synapse;
Biological process	cellular response to organic substance; cellular response to retinoic acid; response to estradiol; cellular response to cGMP; response to hypoxia; negative regulation of neuron differentiation; ejaculation; response to nutrient; vasoconstriction; negative regulation of cerebellar granule cell precursor proliferation; memory; monoamine transport; response to organic substance; brain development; positive regulation of gene expression; positive regulation of cell cycle; serotonin transport; protein complex oligomerization; circadian rhythm; transmembrane transport; social behavior; serotonin uptake; neurotransmitter transport; negative regulation of organ growth; protein homooligomerization; response to toxic substance; negative regulation of synaptic transmission, dopaminergic; brain morphogenesis; positive regulation of serotonin secretion; neurotransmitter biosynthetic process; dopamine uptake involved in synaptic transmission; regulation of thalamus size;
	Sources:Amigo / QuickGO
Orthologs
	6532
	15567
	ENSG00000108576
	ENSMUSG00000020838
	P31645
	Q60857
	NM_001045
	NM_010484
	NP_001036
	NP_034614
	Wikidata
View/Edit Human	View/Edit Mouse

The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.^[5] SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic neuron, in a process known as serotonin reuptake.^[6]

This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. Many antidepressant medications of the SSRI and tricyclic antidepressant classes work by binding to SERT and thus reducing serotonin reuptake.^[7] It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108576 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020838 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "SLC6A4 Gene (Protein Coding)".
^ "SLC6A4 - Sodium-dependent serotonin transporter - Homo sapiens (Human) - SLC6A4 gene & protein".
^ Squire L, et al., eds. (2008). Fundamental neuroscience (3rd ed.). Amsterdam: Elsevier / Academic Press. p. 143. ISBN 978-0-12-374019-9.
^ "Entrez Gene: SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108576 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020838 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "SLC6A4 Gene (Protein Coding)".

[6] "SLC6A4 - Sodium-dependent serotonin transporter - Homo sapiens (Human) - SLC6A4 gene & protein".

[Squire2008-7] Squire L, et al., eds. (2008). Fundamental neuroscience (3rd ed.). Amsterdam: Elsevier / Academic Press. p. 143. ISBN 978-0-12-374019-9.

[8] "Entrez Gene: SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4".

Serotonin transporter information

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Serotonin reuptake inhibitor

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Norepinephrine transporter

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Vesicular monoamine transporter 2

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