Peptide loading complex information

The peptide-loading complex (PLC) is a short-lived, multisubunit membrane protein complex that is located in the endoplasmic reticulum (ER). It orchestrates...

peptides in the lumen of the ER. The peptide-loading process involves several other molecules that form a large multimeric complex called the Peptide...

class I molecules in the ER lumen. Tapasin is one component of the peptide-loading complex, and can be found associated with MHC class I molecules after the...

community, for collaborative learning Perlecan, a protein in humans Peptide loading complex, an intracellular membrane protein matrix Peter Lougheed Centre...

class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates". BMC Evolutionary Biology...

the complex of TAP, tapasin, MHS Class 1, ERp57, and calreticulin is called the peptide-loading complex (PLC). Peptides are loaded to MHC-I peptide binding...

a partly folded state. After the β2-microglobulin binds to the peptide-loading complex (PLC), calreticulin (along with ERp57) takes over the job of chaperoning...

PDIA3 is also part of the major histocompatibility complex (MHC) class I peptide loading complex, which is essential for formation of the final antigen...

transporter is found in the ER lumen associated with the peptide-loading complex (PLC). This complex of β2 microglobulin, calreticulin, ERp57, TAP, tapasin...

gp96 form peptide loading complex for MHCI. This handing over with peptides is important, because HSPs can shield hydrophobic residues in peptides which would...

T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A...

Nonribosomal peptides (NRP) are a class of peptide secondary metabolites, usually produced by microorganisms like bacteria and fungi. Nonribosomal peptides are...

antigens presented by class II peptides are derived from extracellular proteins (not cytosolic as in MHC class I). Loading of a MHC class II molecule occurs...

Peptide T is an HIV entry inhibitor discovered in 1986 by Candace Pert and Michael Ruff, a US neuroscientist and immunologist. Peptide T, and its modified...

Brain natriuretic peptide 32 (BNP), also known as B-type natriuretic peptide, is a hormone secreted by cardiomyocytes in the heart ventricles in response...

I peptide-loading complex (PLC), calreticulin and ERp57 take over the job of chaperoning the MHC class I protein while the tapasin links the complex to...

the chaperone and editing TAPBPR–MHC I complex and the human MHC-I peptide-loading complex. Antigenic peptide recognition on TAP was resolved by DNP-enhanced...

TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2. The membrane-associated protein encoded by this gene is a member of the...

such as MHC I processing mechanism, TAP-independent peptide presentation, MHC I peptide-loading complex (PLC)-independent antigen presentation pathways,...

DM and DO, are used in the internal processing of antigens, loading the antigenic peptides generated from pathogens onto the HLA molecules of antigen-presenting...

Atrial Natriuretic Peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac atria that in humans is...

histocompatibility complex (MHC) molecules, which are found on the surface of most cells in the body. MHC molecules present peptides to T-cells as a way...

repeated PCNA loading for efficient DNA replication. PCNA loading is accomplished by the replication factor C (RFC) complex. The RFC complex is composed...