Tapasin information

TAPBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3F8U
Identifiers
Aliases	TAPBP, NGS17, TAPA, TPN, TPSN, TAP binding protein (tapasin), TAP binding protein
External IDs	OMIM: 601962 MGI: 1201689 HomoloGene: 2401 GeneCards: TAPBP
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,314,254 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,148,266 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; blood; ; spleen; ; monocyte; ; appendix; ; lymph node; ; right adrenal gland; ; right uterine tube; ; duodenum; ; upper lobe of left lung;
	Top expressed in
	subcutaneous adipose tissue; ; blood; ; right lung; ; spleen; ; right lung lobe; ; pituitary gland; ; submandibular gland; ; corneal stroma; ; left colon; ; superior surface of tongue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptide antigen binding; TAP2 binding; unfolded protein binding; ABC-type peptide antigen transporter activity; protein binding; MHC class I protein binding; TAP1 binding; TAP complex binding;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; Golgi membrane; TAP complex; MHC class I peptide loading complex; endoplasmic reticulum; integral component of lumenal side of endoplasmic reticulum membrane; phagocytic vesicle membrane; endoplasmic reticulum-Golgi intermediate compartment membrane;
Biological process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I; regulation of protein complex stability; immune response; peptide antigen stabilization; regulation of gene expression; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane; amide transport; protein-containing complex assembly; MHC class Ib protein complex assembly; peptide transport;
	Sources:Amigo / QuickGO
Orthologs
	6892
	21356
ENSG00000231925; ENSG00000236490; ENSG00000206281; ENSG00000206208; ENSG00000112493;
	n/a
	ENSMUSG00000024308
	O15533
	Q9R233
	NM_003190; NM_172208; NM_172209
	NM_001025313; NM_009318
	NP_003181; NP_757345; NP_757346
	NP_001020484; NP_033344
	Wikidata
View/Edit Human	View/Edit Mouse

TAP-associated glycoprotein, also known as tapasin or TAPBP, is a protein^[5]^[6] that in humans is encoded by the TAPBP gene.^[7]

^ ^a ^b ^c ENSG00000236490, ENSG00000206281, ENSG00000206208, ENSG00000112493 GRCh38: Ensembl release 89: ENSG00000231925, ENSG00000236490, ENSG00000206281, ENSG00000206208, ENSG00000112493 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024308 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sadasivan B, Lehner PJ, Ortmann B, Spies T, Cresswell P (August 1996). "Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP". Immunity. 5 (2): 103–14. doi:10.1016/S1074-7613(00)80487-2. PMID 8769474.
^ Li S, Sjögren HO, Hellman U, Pettersson RF, Wang P (August 1997). "Cloning and functional characterization of a subunit of the transporter associated with antigen processing". Proceedings of the National Academy of Sciences of the United States of America. 94 (16): 8708–13. Bibcode:1997PNAS...94.8708L. doi:10.1073/pnas.94.16.8708. PMC 23091. PMID 9238042.
^ "Entrez Gene: TAPBP TAP binding protein (tapasin)".

[refGRCh38Ensembl-1] ENSG00000236490, ENSG00000206281, ENSG00000206208, ENSG00000112493 GRCh38: Ensembl release 89: ENSG00000231925, ENSG00000236490, ENSG00000206281, ENSG00000206208, ENSG00000112493 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024308 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8769474-5] Sadasivan B, Lehner PJ, Ortmann B, Spies T, Cresswell P (August 1996). "Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP". Immunity. 5 (2): 103–14. doi:10.1016/S1074-7613(00)80487-2. PMID 8769474.

[pmid9238042-6] Li S, Sjögren HO, Hellman U, Pettersson RF, Wang P (August 1997). "Cloning and functional characterization of a subunit of the transporter associated with antigen processing". Proceedings of the National Academy of Sciences of the United States of America. 94 (16): 8708–13. Bibcode:1997PNAS...94.8708L. doi:10.1073/pnas.94.16.8708. PMC 23091. PMID 9238042.

[entrez-7] "Entrez Gene: TAPBP TAP binding protein (tapasin)".

Tapasin information

and 24 Related for: Tapasin information

Tapasin

MHC class I

HBcAg

Antigen presentation

Peptide loading complex

Finnish language

Major histocompatibility complex

TAP1

Cancer immunology

Antigen processing

Transporter associated with antigen processing

Calreticulin

Helsinki slang

WDR46

Calnexin

Minttu Mustakallio

PDIA3

Lapinlahden Linnut

Prefoldin subunit 6

RGL2

Immunoevasin

TAP2

COPG2

COPG