PDIA3, protein disulfide isomerase family A, member 3, ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HEL-S-269, HEL-S-93n, HsT17083, P58, PI-PLC, protein disulfide isomerase family A member 3
antigen processing and presentation of peptide antigen via MHC class I
protein folding in endoplasmic reticulum
cell redox homeostasis
response to endoplasmic reticulum stress
protein retention in ER lumen
protein folding
positive regulation of extrinsic apoptotic signaling pathway
signal transduction
proteolysis
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
cellular response to interleukin-7
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2923
14827
Ensembl
ENSG00000167004
ENSMUSG00000027248
UniProt
P30101
P27773
RefSeq (mRNA)
NM_005313
NM_007952
RefSeq (protein)
NP_005304
NP_031978
Location (UCSC)
Chr 15: 43.75 – 43.77 Mb
Chr 2: 121.24 – 121.27 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Protein disulfide-isomerase A3 (PDIA3), also known as glucose-regulated protein, 58-kD (GRP58), is an isomerase enzyme encoded by the autosomal gene PDIA3 in humans.[5][6][7][8] This protein localizes to the endoplasmic reticulum (ER) and interacts with lectin chaperones calreticulin and calnexin (CNX) to modulate folding of newly synthesized glycoproteins. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000167004 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027248 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Symbol report for PDIA3". HGNC. HUGO Gene Nomenclature Committee. Retrieved 7 February 2024.
^Bourdi M, Demady D, Martin JL, Jabbour SK, Martin BM, George JW, Pohl LR (Nov 1995). "cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase". Archives of Biochemistry and Biophysics. 323 (2): 397–403. doi:10.1006/abbi.1995.0060. PMID 7487104.
^Hirano N, Shibasaki F, Sakai R, Tanaka T, Nishida J, Yazaki Y, Takenawa T, Hirai H (Nov 1995). "Molecular cloning of the human glucose-regulated protein ERp57/GRP58, a thiol-dependent reductase. Identification of its secretory form and inducible expression by the oncogenic transformation". European Journal of Biochemistry. 234 (1): 336–42. doi:10.1111/j.1432-1033.1995.336_c.x. PMID 8529662.
^Koivunen P, Helaakoski T, Annunen P, Veijola J, Räisänen S, Pihlajaniemi T, Kivirikko KI (Jun 1996). "ERp60 does not substitute for protein disulphide isomerase as the beta-subunit of prolyl 4-hydroxylase". The Biochemical Journal. 316. 316 (2): 599–605. doi:10.1042/bj3160599. PMC 1217390. PMID 8687406.
^"Entrez Gene: PDIA3 protein disulfide isomerase family A, member 3".
disulfide-isomerase A3 (PDIA3), also known as glucose-regulated protein, 58-kD (GRP58), is an isomerase enzyme encoded by the autosomal gene PDIA3 in humans. This...
complex consisting of TAP, tapasin, calreticulin, calnexin, and Erp57 (PDIA3). Calnexin acts to stabilize the class I MHC α chains prior to β2m binding...
blood. Alternative, non-genomic pathways may be mediated through either PDIA3 or VDR. The maintenance of electroneutrality requires that the transport...
discovery of various non-genomic actions of vitamin D. The membrane-bound PDIA3 likely serves as an alternate receptor in this pathway. The classical VDR...
Death 4 PDCD6IP PDCD6IP Programmed cell death 6-interacting protein PDIA3PDIA3 Protein Disulfide Isomerase Family A Member 3 PDLIM1 PDLIM1 PDZ and LIM...
(mMRs) – caveolin-associated NRs; diverse putative receptors In addition, PDIA3 is a membrane receptor for the secosteroid calcitriol, the activated form...