MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on professional antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. These cells are important in initiating immune responses.
The antigens presented by class II peptides are derived from extracellular proteins (not cytosolic as in MHC class I).
Loading of a MHC class II molecule occurs by phagocytosis; extracellular proteins are endocytosed, digested in lysosomes, and the resulting epitopic peptide fragments are loaded onto MHC class II molecules prior to their migration to the cell surface.
In humans, the MHC class II protein complex is encoded by the human leukocyte antigen gene complex (HLA). HLAs corresponding to MHC class II are HLA-DP, HLA-DM, HLA-DOA, HLA-DOB, HLA-DQ, and HLA-DR.
Mutations in the HLA gene complex can lead to bare lymphocyte syndrome (BLS), which is a type of MHC class II deficiency.
MHCClassII molecules are a class of major histocompatibility complex (MHC) molecules normally found only on professional antigen-presenting cells such...
MHCclass I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHCclassII) and are found on...
subgroups: MHCclass I, MHCclassII, and MHCclass III. Among all those genes present in MHC, there are two types of genes coding for the proteins MHCclass I...
MHCclass III is a group of proteins belonging the class of major histocompatibility complex (MHC). Unlike other MHC types such as MHCclass I and MHC...
generated in the endocytic vesicles after internalisation are bound to MHCclassII (MHC-II). Cellular membranes separate these two cellular environments - intracellular...
domains have binding regions for the major histocompatibility complex classII (MHCclassII) and the T-cell receptor (TCR), respectively. By bridging these...
electrical appliance Class II gaming ClassII gene ClassII PI 3-kinases ClassII railroad ClassII star MHCclassIIClass 2 (disambiguation) This disambiguation...
Invariant chain, a polypeptide involved in the formation and transport of MHCclassII protein Optic nerve, the second cranial nerve Income inequality, or the...
T-cell recognizes only a few MHCclassII-peptide combinations. Once a T-cell recognizes a peptide within an MHCclassII molecule, it can stimulate B-cells...
antigens on class I or classII major histocompatibility complex (MHC) molecules is dependent on which pathway is used. Both MHCclass I and II are required...
(Abbreviated Ii) is a polypeptide which plays a critical role in antigen presentation. It is involved in the formation and transport of MHCclassII peptide...
MHC-restricted antigen recognition, or MHC restriction, refers to the fact that a T cell can interact with a self-major histocompatibility complex molecule...
histocompatibility complex (MHC) classII genes are important in the immune response. Major histocompatibility complex (MHC) II is found on antigen-presenting...
(Oct 1993). "Complementation cloning of an MHCclassII transactivator mutated in hereditary MHCclassII deficiency (or bare lymphocyte syndrome)". Cell...
antigens. Positive selection selects cells which are able to bind MHCclass I or II molecules with at least a weak affinity. This eliminates (by a process...
1942) is an American immunologist. He is best known for his discovery of MHCclassII and for his seminal studies in the fields of transplant immune tolerance...
cells in any given vertebrate express MHC, but most cells only express MHCclass I. The other class of MHC, ClassII, is found only on "professional" antigen...
presented on the MHCclassII molecules of the B cell. Once this happens a T helper cell which is able to identify the antigen bound to the MHC interacts with...
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