Calnexin information

CANX
Identifiers
Aliases	CANX, CNX, IP90, P90, calnexin
External IDs	OMIM: 114217 MGI: 88261 HomoloGene: 1324 GeneCards: CANX
Gene location (Human)
Chr.	Chromosome 5 (human)
End	179,730,925 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	50,216,500 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; islet of Langerhans; ; Achilles tendon; ; bone marrow cells; ; thymus; ; corpus callosum; ; smooth muscle tissue; ; sural nerve; ; placenta; ; body of pancreas;
	Top expressed in
	medullary collecting duct; ; paraventricular nucleus of hypothalamus; ; primitive streak; ; renal corpuscle; ; lacrimal gland; ; arcuate nucleus; ; median eminence; ; dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; globus pallidus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; apolipoprotein binding; unfolded protein binding; metal ion binding; ionotropic glutamate receptor binding; carbohydrate binding; RNA binding; protein binding;
Cellular component	cytoplasm; integral component of membrane; mitochondria-associated endoplasmic reticulum membrane; rough endoplasmic reticulum; ribosome; endoplasmic reticulum lumen; endoplasmic reticulum membrane; membrane; melanosome; myelin sheath; dendritic spine; smooth endoplasmic reticulum; axon; neuronal cell body; endoplasmic reticulum; dendrite cytoplasm; integral component of lumenal side of endoplasmic reticulum membrane; extracellular exosome; extracellular matrix; protein-containing complex; endoplasmic reticulum quality control compartment; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic active zone membrane;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; human ageing; protein folding in endoplasmic reticulum; protein secretion; clathrin-dependent endocytosis; synaptic vesicle endocytosis; protein folding; chaperone-mediated protein folding; interleukin-12-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	821
	12330
	ENSG00000283777; ENSG00000127022
	ENSMUSG00000020368
	P27824
	P35564
	NM_001024649; NM_001746
	NM_001110499; NM_001110500; NM_007597
NP_001019820; NP_001737; NP_001350922; NP_001350923; NP_001350924;
	NP_001350925; NP_001350926; NP_001350927; NP_001350928; NP_001350929; NP_001350930
	NP_001103969; NP_001103970; NP_031623
	Wikidata
View/Edit Human	View/Edit Mouse

Calnexin (CNX) is a 67kDa integral protein (that appears variously as a 90kDa, 80kDa, or 75kDa band on western blotting depending on the source of the antibody) of the endoplasmic reticulum (ER). It consists of a large (50 kDa) N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail.^[5] In humans, calnexin is encoded by the gene CANX.^[6]

^ ^a ^b ^c ENSG00000127022 GRCh38: Ensembl release 89: ENSG00000283777, ENSG00000127022 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020368 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wada I, Rindress D, Cameron PH, Ou WJ, Doherty JJ 2nd, Louvard D, Bell AW, Dignard D, Thomas DY, Bergeron JJ (1991). "SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane". J Biol Chem. 226 (29): 19599–610. doi:10.1016/S0021-9258(18)55036-5. PMID 1918067.
^ Paskevicius T, Farraj RA, Michalak M, Agellon LB (2023). Lim D (ed.). "Calnexin, More Than Just a Molecular Chaperone". Cells. 12 (3): 403. doi:10.3390/cells12030403. PMC 9913998. PMID 36766745. Article No. 403.

[refGRCh38Ensembl-1] ENSG00000127022 GRCh38: Ensembl release 89: ENSG00000283777, ENSG00000127022 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020368 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Wada-5] Wada I, Rindress D, Cameron PH, Ou WJ, Doherty JJ 2nd, Louvard D, Bell AW, Dignard D, Thomas DY, Bergeron JJ (1991). "SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane". J Biol Chem. 226 (29): 19599–610. doi:10.1016/S0021-9258(18)55036-5. PMID 1918067.

[6] Paskevicius T, Farraj RA, Michalak M, Agellon LB (2023). Lim D (ed.). "Calnexin, More Than Just a Molecular Chaperone". Cells. 12 (3): 403. doi:10.3390/cells12030403. PMC 9913998. PMID 36766745. Article No. 403.

Calnexin information

and 22 Related for: Calnexin information

Calnexin

MHC class I

Calreticulin

Endoplasmic reticulum

Antigen presentation

Antigen processing

Glycoprotein

Unfolded protein response

Inositol trisphosphate

Glycan

Calcium signaling

Calreticulin protein family

Calmodulin

Peripheral myelin protein 22

UGGT

Ryanodine receptor

Annexin A5

PDIA3

Housekeeping gene

Phospholamban

S100 protein

Osteocalcin