regulation of high voltage-gated calcium channel activity
neuropeptide signaling pathway
female pregnancy
regulation of cardiac conduction
negative regulation of collecting lymphatic vessel constriction
positive regulation of potassium ion export across plasma membrane
positive regulation of heart rate
positive regulation of delayed rectifier potassium channel activity
cGMP biosynthetic process
regulation of blood pressure
negative regulation of systemic arterial blood pressure
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
transcription initiation from RNA polymerase II promoter
regulation of atrial cardiac muscle cell membrane repolarization
response to insulin
cell growth involved in cardiac muscle cell development
negative regulation of cell growth
cardiac muscle hypertrophy in response to stress
cellular response to mechanical stimulus
receptor guanylyl cyclase signaling pathway
protein folding
regulation of signaling receptor activity
positive regulation of histamine secretion by mast cell
positive regulation of cGMP-mediated signaling
cGMP-mediated signaling
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4878
230899
Ensembl
ENSG00000175206
ENSMUSG00000041616
UniProt
P01160
P05125
RefSeq (mRNA)
NM_006172
NM_008725
RefSeq (protein)
NP_006163
NP_032751
Location (UCSC)
Chr 1: 11.85 – 11.85 Mb
Chr 4: 148.09 – 148.09 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Atrial Natriuretic Peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac atria that in humans is encoded by the NPPA gene.[5] Natriuretic peptides (ANP, BNP, and CNP) are a family of hormone/paracrine factors that are structurally related.[6] The main function of ANP is causing a reduction in expanded extracellular fluid (ECF) volume by increasing renal sodium excretion. ANP is synthesized and secreted by cardiac muscle cells in the walls of the atria in the heart. These cells contain volume receptors which respond to increased stretching of the atrial wall due to increased atrial blood volume.
Reduction of blood volume by ANP can result in secondary effects such as reduction of extracellular fluid (ECF) volume, improved cardiac ejection fraction with resultant improved organ perfusion, decreased blood pressure, and increased serum potassium. These effects may be blunted or negated by various counter-regulatory mechanisms operating concurrently on each of these secondary effects.
Brain natriuretic peptide (BNP) – a misnomer; it is secreted by cardiac muscle cells in the heart ventricles – is similar to ANP in its effect. It acts via the same receptors as ANP does, but with 10-fold lower affinity than ANP. The biological half-life of BNP, however, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these peptides better choices than ANP for diagnostic blood testing.
^ abcGRCh38: Ensembl release 89: ENSG00000175206 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000041616 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Macchia DD (December 1987). "Atrial natriuretic factor: a hormone secreted by the heart". Pharmaceutisch Weekblad. Scientific Edition. 9 (6): 305–14. doi:10.1007/bf01956510. PMID 2829109. S2CID 21363735.
^Cite error: The named reference Potter_2009 was invoked but never defined (see the help page).
and 26 Related for: Atrial natriuretic peptide information
diuretic, natriuretic, and vasodilatory effects. There are three main types of natriureticpeptides: atrialnatriureticpeptide (ANP), brain natriuretic peptide...
An atrialnatriureticpeptide receptor is a receptor for atrialnatriureticpeptide. NPRA and NPRB are linked to guanylyl cyclases, while NPRC is G-protein-linked...
hypersecretion Endogenous natriuretic hormones include: Atrialnatriureticpeptide Brain natriureticpeptide C-type natriureticpeptide This is a natural process...
Corin, also called atrialnatriureticpeptide-converting enzyme, is a protein that in humans is encoded by the CORIN gene. Human corin, a polypeptide of...
acid peptide C-type natriureticpeptide (CNP). Natriureticpeptides comprise a family of 3 structurally related molecules: atrialnatriureticpeptide (ANP)...
Natriureticpeptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrialnatriureticpeptide receptor...
Dendroaspis natriureticpeptide (DNP) is a 38-residue peptide and a member of natriureticpeptide family. It is structurally similar to the atrialnatriuretic peptide...
glucagon, epinephrine, norepinephrine, growth hormone, atrialnatriureticpeptide, brain natriureticpeptide, and cortisol. In the body, stores of fat are referred...
with its general pressor and pro-volumic effects on the body. Atrialnatriureticpeptide inhibits AVP secretion, in part by inhibiting Angiotensin II-induced...
a blood volume increase in the atria, the atrial stretch triggers the release of AtrialNatriureticPeptide (ANP), and a signal is transmitted from the...
parathyroid hormone (calcium, phosphate), atrialnatriureticpeptide (sodium) and brain natriureticpeptide (sodium). A countercurrent system in the renal...
to: ANH, ICAO airline code for Alajnihah Airways Atrialnatriuretic hormone or atrialnatriureticpeptide Alliance for Natural Health, UK A New Hope, the...
"Glucocorticoids improve renal responsiveness to atrialnatriureticpeptide by up-regulating natriureticpeptide receptor-A expression in the renal inner medullary...
non-GPCR targets include: insulin-like peptides and tyrosine-kinase receptors in Drosophila and atrialnatriureticpeptide and eclosion hormone with membrane-bound...
slower-acting systems to regulate blood pressure: the heart releases atrialnatriureticpeptide when blood pressure is too high, and the kidneys sense and correct...
stimulated by angiotensin II and aldosterone, and inhibited by atrialnatriureticpeptide. It is very efficient, since more than 25,000 mmoles/day of sodium...
Anaritide (also known as human atrialnatriureticpeptide [102-126]) is a synthetic analogue of atrialnatriureticpeptide (ANP). Anartidine has the following...
can improve renal responsiveness to atrialnatriureticpeptide by increasing the density of natriureticpeptide receptor type A in the renal inner medullary...
Natriureticpeptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C), also known as NPR3, is an atrialnatriureticpeptide receptor...
renin, angiotensin II, aldosterone, antidiuretic hormone, and atrialnatriureticpeptide, among others. Filtration, which takes place at the renal corpuscle...
cell clusters that secrete hormones. Examples include the heart (atrialnatriureticpeptide); gastrointestinal tract organs (gastrin, secretin, and others);...