Transporter associated with antigen processing information
Protein family
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
Symbol
TAP1
Alt. symbols
ABCB2
NCBI gene
6890
HGNC
43
OMIM
170260
RefSeq
NM_000593
UniProt
Q03518
Other data
Locus
Chr. 6 p21.3
Search for
Structures
Swiss-model
Domains
InterPro
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
Symbol
TAP2
Alt. symbols
ABCB3
NCBI gene
6891
HGNC
44
OMIM
170261
RefSeq
NM_000544
UniProt
Q03519
Other data
Locus
Chr. 6 p21.3
Search for
Structures
Swiss-model
Domains
InterPro
Transporter associated with antigen processing (TAP) protein complex belongs to the ATP-binding-cassette transporter family.[1] It delivers cytosolic peptides into the endoplasmic reticulum (ER), where they bind to nascent MHC class I molecules.[2]
The TAP structure is formed of two proteins: TAP-1 and TAP-2, which have one hydrophobic region and one ATP-binding region each. They assemble into a heterodimer, which results in a four-domain transporter.[3]
^Daumke O, Knittler MR (2001). "Functional asymmetry of the ATP-binding-cassettes of the ABC transporter TAP is determined by intrinsic properties of the nucleotide binding domains". Eur. J. Biochem. 268 (17): 4776–86. doi:10.1046/j.1432-1327.2001.02406.x. PMID 11532014.
^Suh WK, Cohen-Doyle MF, Fruh K, Wang K, Peterson PA, Williams DB (1994). "Interaction of MHC class I molecules with the transporter associated with antigen processing". Science. 264 (5163): 1322–6. Bibcode:1994Sci...264.1322S. doi:10.1126/science.8191286. PMID 8191286.
^Janeway CA, Travers P, Walport M, Shlomchik M (2001). "Chapter 5, Antigen Presentation to T-lymphocytes". In Janeway, Charles (ed.). Immunobiology: the immune system in health and disease (5th ed.). New York: Garland. ISBN 0-8153-3642-X.
and 24 Related for: Transporter associated with antigen processing information
Transporterassociatedwithantigenprocessing (TAP) protein complex belongs to the ATP-binding-cassette transporter family. It delivers cytosolic peptides...
Transporterassociatedwithantigenprocessing 1 (TAP1) is a protein that in humans is encoded by the TAP1 gene. A member of the ATP-binding cassette transporter...
Antigenprocessing, or the cytosolic pathway, is an immunological process that prepares antigens for presentation to special cells of the immune system...
class I molecules and the transporterassociatedwithantigenprocessing (TAP), which is required for the transport of antigenic peptides across the endoplasmic...
studying protein interactions Timor–Alor–Pantar languages Transporterassociatedwithantigenprocessing (TAP), a protein complex Twin anemia-polycythemia sequence...
antigen presentation pathway, what leads into down-regulation of tumor antigen presentations. Defects are for example in transporterassociatedwith antigen...
function of MHC molecules: binding an antigen derived from self-proteins, or from pathogens, and bringing the antigen presentation to the cell surface for...
are imported into the endoplasmic reticulum via the transporterassociatedwithantigenprocessing, allowing them to bind to MHCI-molecules that are subsequently...
the ER is accomplished by the transporterassociatedwithantigenprocessing (TAP). TAP is a member of the ABC transporter family and is a heterodimeric...
"Structure of the ABC ATPase domain of human TAP1, the transporterassociatedwithantigenprocessing". The EMBO Journal. 20 (17): 4964–72. doi:10.1093/emboj/20...
complex to the transporterassociatedwithantigenprocessing (TAP) complex. This association prepares the MHC class I for binding an antigen for presentation...
assembly consists of seven subunits, including the transportersassociatedwithantigenprocessing (TAP1 and TAP2 – jointly referred to as TAP), the oxidoreductase...
with ERp57) takes over the job of chaperoning the MHC class I protein while the tapasin links the complex to the transporterassociatedwithantigen processing...
"Structure of the ABC ATPase domain of human TAP1, the transporterassociatedwithantigenprocessing". EMBO J. 20 (17): 4964–72. doi:10.1093/emboj/20.17...
TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2. The membrane-associated protein encoded by this gene is a member of the...
also reduced, due to impaired development with the absence of MHC II. TAP (transporterassociatedwithantigen presentation) deficiency syndrome is the...
lumen by the transporterassociatedwithantigenprocessing (TAP) and is presented on the cell surface on H2-Db major histocompatibility antigen I (MHC I)...
2005). "Cytoplasmic domains of the transporterassociatedwithantigenprocessing and P-glycoprotein interact with subunits of the proteasome". Molecular...
Suita N, Maeda M (2003). "Gene organization of human transporterassociatedwithantigenprocessing-like (TAPL, ABCB9): analysis of alternative splicing...
independent transport systems, namely, the O-antigentransporter Wzx (RfbX) and the ATP binding cassette (ABC) transporter MsbA that flips the lipid A-core moiety...
cycle.; Kidd antigen protein – urea transporter; RHAG – gas transporter, probably of carbon dioxide, defines Rh Blood Group and the associated unusual blood...
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