TAP2 information

TAP2
Identifiers
Aliases	TAP2, ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), transporter 2, ATP binding cassette subfamily B member
External IDs	OMIM: 170261; MGI: 98484; HomoloGene: 37323; GeneCards: TAP2; OMA:TAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,838,739 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,435,295 bp
RNA expression pattern
	Top expressed in
	appendix; ; lymph node; ; monocyte; ; granulocyte; ; duodenum; ; apex of heart; ; spleen; ; stromal cell of endometrium; ; mucosa of transverse colon; ; blood;
	Top expressed in
	thymus; ; spleen; ; duodenum; ; subcutaneous adipose tissue; ; jejunum; ; bone marrow; ; submandibular gland; ; lip; ; white adipose tissue; ; right lung;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	MHC protein binding; ATPase-coupled transmembrane transporter activity; nucleotide binding; ABC-type peptide transporter activity; transporter activity; tapasin binding; MHC class Ib protein binding; ABC-type peptide antigen transporter activity; ATPase activity; protein binding; TAP1 binding; ATP binding; peptide transmembrane transporter activity; MHC class I protein binding; TAP2 binding;
Cellular component	TAP complex; endoplasmic reticulum membrane; membrane; integral component of endoplasmic reticulum membrane; integral component of membrane; endoplasmic reticulum; nuclear speck; phagocytic vesicle membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; MHC class I peptide loading complex;
Biological process	adaptive immune response; immune system process; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; transmembrane transport; protein transport; peptide transport; viral process; cytosol to endoplasmic reticulum transport; antigen processing and presentation of endogenous peptide antigen via MHC class I; peptide antigen transport; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane; transport;
	Sources:Amigo / QuickGO
Orthologs
	6891
	21355
ENSG00000204267; ENSG00000206299; ENSG00000228582; ENSG00000206235; ENSG00000225967;
	ENSG00000237599; ENSG00000223481; ENSG00000232326
	ENSMUSG00000024339
	Q03519
	P36371
	NM_018833; NM_000544; NM_001290043
	NM_011530
	NP_000535; NP_001276972; NP_061313
	NP_035660
	Wikidata
View/Edit Human	View/Edit Mouse

TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2.^[5]^[6]^[7]

^ ^a ^b ^c ENSG00000206299, ENSG00000228582, ENSG00000206235, ENSG00000225967, ENSG00000237599, ENSG00000223481, ENSG00000232326 GRCh38: Ensembl release 89: ENSG00000204267, ENSG00000206299, ENSG00000228582, ENSG00000206235, ENSG00000225967, ENSG00000237599, ENSG00000223481, ENSG00000232326 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024339 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–73. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427.
^ Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A. 88 (22): 10094–8. Bibcode:1991PNAS...8810094B. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428.
^ Hahn Y, Lee B (Feb 2006). "Human-specific nonsense mutations identified by genome sequence comparisons". Hum Genet. 119 (1–2): 169–78. doi:10.1007/s00439-005-0125-6. PMID 16395595. S2CID 21059468.

[refGRCh38Ensembl-1] ENSG00000206299, ENSG00000228582, ENSG00000206235, ENSG00000225967, ENSG00000237599, ENSG00000223481, ENSG00000232326 GRCh38: Ensembl release 89: ENSG00000204267, ENSG00000206299, ENSG00000228582, ENSG00000206235, ENSG00000225967, ENSG00000237599, ENSG00000223481, ENSG00000232326 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024339 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1529427-5] Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–73. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427.

[pmid1946428-6] Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A. 88 (22): 10094–8. Bibcode:1991PNAS...8810094B. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428.

[pmid16395595-7] Hahn Y, Lee B (Feb 2006). "Human-specific nonsense mutations identified by genome sequence comparisons". Hum Genet. 119 (1–2): 169–78. doi:10.1007/s00439-005-0125-6. PMID 16395595. S2CID 21059468.

TAP2 information

and 17 Related for: TAP2 information

TAP2

Promo Parachutiste

MHC class I

Transporter associated with antigen processing

TAP1

M62812

ABC transporter

List of primary immunodeficiencies

Bare lymphocyte syndrome

Tapasin

Takatika Grit

Immunoproteasome

Peptide loading complex

Transmembrane domain of ABC transporters

PSMB9

List of OMIM disorder codes

ABCB9