negative regulation of cell population proliferation
stem cell differentiation
positive regulation of peptidyl-serine phosphorylation of STAT protein
positive regulation of MAPK cascade
positive regulation of peptidyl-serine phosphorylation
spongiotrophoblast differentiation
lung development
positive regulation of histone H3-K27 acetylation
multicellular organism development
lung lobe morphogenesis
muscle organ morphogenesis
maternal process involved in female pregnancy
negative regulation of hormone secretion
leukemia inhibitory factor signaling pathway
regulation of metanephric nephron tubule epithelial cell differentiation
regulation of cell differentiation
positive regulation of gene expression
stem cell population maintenance
positive regulation of peptidyl-tyrosine phosphorylation
regulation of RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of astrocyte differentiation
negative regulation of ERK1 and ERK2 cascade
neuron development
decidualization
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
lung alveolus development
positive regulation of macrophage differentiation
blood vessel remodeling
trophoblast giant cell differentiation
lung vasculature development
positive regulation of transcription by RNA polymerase II
positive regulation of protein localization to nucleus
embryo implantation
negative regulation of meiotic nuclear division
immune response
positive regulation of cell population proliferation
positive regulation of tyrosine phosphorylation of STAT protein
tyrosine phosphorylation of STAT protein
regulation of signaling receptor activity
cytokine-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3976
16878
Ensembl
ENSG00000128342
ENSMUSG00000034394
UniProt
P15018
P09056
RefSeq (mRNA)
NM_001257135 NM_002309
NM_001039537 NM_008501
RefSeq (protein)
NP_001244064 NP_002300
NP_001034626 NP_032527
Location (UCSC)
Chr 22: 30.24 – 30.25 Mb
Chr 11: 4.21 – 4.22 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate.
^ abcGRCh38: Ensembl release 89: ENSG00000128342 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000034394 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
and 25 Related for: Leukemia inhibitory factor information
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Differentiation 118), is a subunit of a receptor for leukemiainhibitoryfactor. The leukemiainhibitoryfactor (LIF) is a polyfunctional cytokine that affects...
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Shew JY, Ho HN, Hsu WL, Yang YS (October 1999). "Expression of leukemiainhibitoryfactor and its receptor in preimplantation embryos". Fertil. Steril....
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growth factor receptor (EGFR) mutation BCR-ABL is a constitutively activated tyrosine kinase that is associated with chronic myeloid leukemia. It is formed...
Coupey L, et al. (1996). "Binding interactions of leukemiainhibitoryfactor and ciliary neurotrophic factor with the different subunits of their high affinity...
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has...
album A Natural Death "Líf", a song by Hildur Vala Einarsdóttir Leukemiainhibitoryfactor, a cytokine that affects cell growth and development Laser-induced...
of acidic amino acids located between the D1 and D2 domains has auto-inhibitory functions. This 'acid box' motif interacts with the heparan sulfate binding...
lab with media containing serum and leukemiainhibitoryfactor or serum-free media supplements with two inhibitory drugs ("2i"), the MEK inhibitor PD03259010...
example, they have substantially improved outcomes in chronic myelogenous leukemia. They have also been used to treat other diseases, such as idiopathic pulmonary...
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Fibroblast growth factor 2, also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2...
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Global Information
