regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of axonogenesis
positive regulation of gene expression
positive regulation of apoptotic process
nerve growth factor processing
extrinsic apoptotic signaling pathway via death domain receptors
phosphatidylinositol-mediated signaling
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
microtubule-based movement
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of Ras protein signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
peripheral nervous system development
memory
negative regulation of cell population proliferation
regulation of signaling receptor activity
nerve development
nerve growth factor signaling pathway
positive regulation of DNA binding
positive regulation of neuron differentiation
positive regulation of collateral sprouting
modulation of chemical synaptic transmission
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4803
18049
Ensembl
ENSG00000134259
ENSMUSG00000027859
UniProt
P01138
P01139
RefSeq (mRNA)
NM_002506
NM_001112698 NM_013609
RefSeq (protein)
NP_002497
NP_001106168 NP_038637
Location (UCSC)
Chr 1: 115.29 – 115.34 Mb
Chr 3: 102.38 – 102.43 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described. Since it was first isolated by Nobel Laureates Rita Levi-Montalcini and Stanley Cohen in 1956, numerous biological processes involving NGF have been identified, two of them being the survival of pancreatic beta cells and the regulation of the immune system.
^ abcGRCh38: Ensembl release 89: ENSG00000134259 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027859 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
and 24 Related for: Nerve growth factor information
Nervegrowthfactor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival...
Nervegrowthfactor (NGF) inhibitors are a class of compounds that inhibit the action of the neurotrophin nervegrowthfactor by targeting NGF molecules...
Epidermal growthfactor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has...
for neurotrophic factor, but the term neurotrophin is more generally reserved for four structurally related factors: nervegrowthfactor (NGF), brain-derived...
Oxervate, also known as recombinant human nervegrowthfactor (rhNGF), is a recombinant form of human nervegrowthfactor (NGF). In July 2017, it was approved...
Neurotrophic factor receptors or neurotrophin receptors are a group of growthfactor receptors which specifically bind to neurotrophins (neurotrophic factors). Two...
cell organelles. Her cell culture method led to the discovery of nervegrowthfactor, a protein that regulates development and survival of neurones. Meyer...
neurotrophic factors are being intensely studied for use in bioartificial nerve conduits because they are necessary in vivo for directing axon growth and regeneration...
neurotrophic factors such as nervegrowthfactor (NGF) and ciliary neurotrophic factor (CNTF), which promote growth, of both the damaged nerve and supporting...
cells stop dividing and terminally differentiate when treated with nervegrowthfactor or dexamethasone. This makes PC12 cells useful as a model system...
Fibroblast growthfactors (FGF) are a family of cell signalling proteins produced by macrophages; they are involved in a wide variety of processes, most...
such as ATP, which can be detected by P2 purinergic receptors, or nervegrowthfactor, which can be detected by Tropomyosin receptor kinase A (TrkA). Chemical...
Tropomyosin receptor kinase A (TrkA), also known as high affinity nervegrowthfactor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming...
TrkA and TrkC. There are other neurotrophic factors structurally related to BDNF: NGF (for nervegrowthfactor), NT-3 (for neurotrophin-3) and NT-4 (for...
fruiting body of Hericium erinaceum (lion's mane mushroom) that promote nervegrowthfactor synthesis in vitro. Kawagishi, Hirokazu; Ando, Motoharu; Shinba,...
fiber degeneration of affected neurons and their projecting axons. Nervegrowthfactor protects cholinergic neurons. The small non-toxic molecule urea has...
neuroscientist Rita Levi-Montalcini resulted in the discovery of nervegrowthfactor. In 1951 he and Howard Hamilton published a standardized stage series...
analgesic effects of alpha-2 adrenergic receptor agonists bedinvetmab - nervegrowthfactor inhibitor monoclonal antibody used for osteoarthritis in dogs benazepril...