negative regulation of photoreceptor cell differentiation
positive regulation of gene expression
signal transduction
positive regulation of axon regeneration
positive regulation of cell population proliferation
astrocyte activation
positive regulation of tyrosine phosphorylation of STAT protein
growth
regulation of signaling receptor activity
cytokine-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1270
12803
Ensembl
ENSG00000242689
ENSMUSG00000079415
UniProt
P26441
P51642
RefSeq (mRNA)
NM_000614
NM_053007 NM_170786
RefSeq (protein)
NP_000605
NP_740756
Location (UCSC)
Chr 11: 58.62 – 58.63 Mb
Chr 19: 12.74 – 12.74 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene.[5][6][7]
The protein encoded by this gene is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations including astrocytes. It is a hypothalamic neuropeptide that is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also cotranscribed with the upstream ZFP91 gene. Cotranscription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor.[7]
CNTF has also been shown to be expressed by cells on the bone surface, and to reduce the activity of bone-forming cells (osteoblasts).[8]
^ abcGRCh38: Ensembl release 89: ENSG00000242689 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000079415 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lam A, Fuller F, Miller J, Kloss J, Manthorpe M, Varon S, Cordell B (Sep 1991). "Sequence and structural organization of the human gene encoding ciliary neurotrophic factor". Gene. 102 (2): 271–6. doi:10.1016/0378-1119(91)90089-T. PMID 1840538.
^Bazan JF (Sep 1991). "Neuropoietic cytokines in the hematopoietic fold". Neuron. 7 (2): 197–208. doi:10.1016/0896-6273(91)90258-2. PMID 1714745. S2CID 24161982.
^McGregor NE, Poulton IJ, Walker EC, Pompolo S, Quinn JM, Martin TJ, Sims NA (Mar 2010). "Ciliary neurotrophic factor inhibits bone formation and plays a sex-specific role in bone growth and remodeling". Calcified Tissue International. 86 (3): 261–70. doi:10.1007/s00223-010-9337-4. PMID 20157807. S2CID 23699865.
and 26 Related for: Ciliary neurotrophic factor information
Ciliaryneurotrophicfactor is a protein that in humans is encoded by the CNTF gene. The protein encoded by this gene is a polypeptide hormone and neurotrophic...
also been shown to increase astrocyte proliferation in vitro. Ciliaryneurotrophicfactor (CNTF) is a cytosolic protein that is not secreted. CNTF has...
important role in not only producing neurotrophicfactors such as nerve growth factor (NGF) and ciliaryneurotrophicfactor (CNTF), which promote growth, of...
affect other systems, including the ciliaryneurotrophicfactor, growth hormone and prolactin. Leukemia inhibitory factor receptor has been shown to interact...
kinase, Akt, and PKC pathways. CNTF: Ciliaryneurotrophicfactor is another protein that acts as a survival factor for motor neurons. CNTF acts via a receptor...
closely related to other proteins called cardiotrophin-1 and ciliaryneurotrophicfactor. GRCh38: Ensembl release 89: ENSG00000175505 – Ensembl, May 2017...
complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliaryneurotrophicfactor receptors. The complex can promote survival...
derived neurotrophicfactor (GDNF), and ciliaryneurotrophicfactor (CNTF) was presented to Dorsal root ganglion cultures in vitro. One factor from each...
to these four neurotrophins, the GDNF family of ligands, and ciliaryneurotrophicfactor (CNTF), among other biomolecules. Neurotrophin-6 and neurotrophin-7...
include the cytokines interleukin 6 (IL-6), ciliaryneurotrophicfactor (CNTF), and leukemia inhibitory factor (LIF). Although many of these specific modulatory...
insult. Upregulation of GFAP, which is induced by FGF, TGFB, and ciliaryneurotrophicfactor (CNTF), is a classic marker for reactive gliosis. Axon regeneration...
receptor family. This particular receptor is very similar to ciliaryneurotrophicfactor, since both contain an extracellular region with a 2-domain structure...
(neovascularisation), treatment with Anti-VEGF can be helpful. Ciliaryneurotrophicfactor (CNTF) is believed to have neuroprotective properties and could...
brain derived neurotrophicfactor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). Other factors are ciliaryneurotrophicfactor (CNTF), glial...
Global Information
