positive regulation of corticotropin-releasing hormone secretion
positive regulation of MAP kinase activity
calcium ion homeostasis
ossification
monocyte chemotaxis
cytokine-mediated signaling pathway
osteoclast differentiation
ERK1 and ERK2 cascade
paracrine signaling
positive regulation of DNA-binding transcription factor activity
positive regulation of osteoclast differentiation
tumor necrosis factor-mediated signaling pathway
positive regulation of intracellular signal transduction
positive regulation of bone resorption
mammary gland alveolus development
positive regulation of JNK cascade
bone resorption
positive regulation of osteoclast development
multicellular organism development
positive regulation of T cell activation
positive regulation of homotypic cell-cell adhesion
positive regulation of NF-kappaB transcription factor activity
positive regulation of fever generation by positive regulation of prostaglandin secretion
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
regulation of osteoclast differentiation
immune response
animal organ morphogenesis
positive regulation of I-kappaB kinase/NF-kappaB signaling
TNFSF11-mediated signaling pathway
positive regulation of phosphorylation
protein homooligomerization
positive regulation of transcription by RNA polymerase II
osteoclast proliferation
calcium-mediated signaling
cellular response to leukemia inhibitory factor
regulation of signaling receptor activity
tooth eruption
bone development
positive regulation of gene expression
osteoclast development
regulation of actin binding
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
8600
21943
Ensembl
ENSG00000120659
ENSMUSG00000022015
UniProt
O14788
O35235
RefSeq (mRNA)
NM_003701 NM_033012
NM_011613
RefSeq (protein)
NP_003692 NP_143026
NP_035743
Location (UCSC)
Chr 13: 42.56 – 42.61 Mb
Chr 14: 78.51 – 78.55 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Receptor activator of nuclear factor kappa-Β ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene.[5][6]
RANKL is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily.[7] RANKL has been identified to affect the immune system and control bone regeneration and remodeling. RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin (OPG), a ligand for the receptor RANK and controls cell proliferation by modifying protein levels of Id4, Id2 and cyclin D1.[8][9] RANKL is expressed in several tissues and organs including: skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.[9] Variation in concentration levels of RANKL throughout several organs reconfirms the importance of RANKL in tissue growth (particularly bone growth) and immune functions within the body.
^ abcGRCh38: Ensembl release 89: ENSG00000120659 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022015 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wong BR, Rho J, Arron J, Robinson E, Orlinick J, Chao M, Kalachikov S, Cayani E, Bartlett FS, Frankel WN, Lee SY, Choi Y (October 1997). "TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells". J. Biol. Chem. 272 (40): 25190–4. doi:10.1074/jbc.272.40.25190. PMID 9312132.
^Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L (November 1997). "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function". Nature. 390 (6656): 175–9. Bibcode:1997Natur.390..175A. doi:10.1038/36593. PMID 9367155. S2CID 4373990.
Receptor activator of nuclear factor kappa-Β ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced...
Rankl is a surname. Notable people with the surname include: George Rankl (1867–?), American politician Karl Rankl (1898–1968), Austrian-British conductor...
joint and muscle pain in the arms or legs. Denosumab is an inhibitor of RANKL (receptor activator of nuclear factor kappa-Β ligand), which works by decreasing...
George Rankl (February 28, 1867 in Milwaukee, Wisconsin – ?) was a member of the Wisconsin State Assembly Rankl was elected to the Assembly in 1902. He...
(December 2012). "Osteopetrosis rescue upon RANKL administration to Rankl(-/-) mice: a new therapy for human RANKL-dependent ARO". Journal of Bone and Mineral...
Robert A. Rankl (born c. 1976) is an American college football coach. He is the head football coach for Alfred University; a position he has held since...
expression of RANKL and inhibits their secretion of osteoprotegerin (OPG). Free OPG competitively binds to RANKL as a decoy receptor, preventing RANKL from interacting...
decoy receptor for receptor activator of nuclear factor kappa-B ligand (RANKL). OPG also binds to TNF-related apoptosis-inducing ligand (TRAIL) and inhibits...
Karl Rankl (1 October 1898 – 6 September 1968) was a British conductor and composer who was of Austrian birth. A pupil of the composers Schoenberg and...
molecular sub-family. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation...
monocyte/macrophage derived cells. RANKL is a member of the tumour necrosis family (TNF), and is essential in osteoclastogenesis. RANKL knockout mice exhibit a phenotype...
marrow-derived membrane and soluble cytokines and growth factors (e.g. M-CSF, RANKL, VEGF and IL-6 family). It is in this way that the body is able to maintain...
Surface RANKL on osteoblasts as well as secreted RANKL provide necessary signals for osteoclast precursors to differentiate into osteoclasts. RANKL expression...
pluripotent cells in osteoblasts and inhibiting the RANKL/RANK pathway and osteoclastogenesis. RANKL is a member of the TNF superfamily of ligands. Through...
pro-inflammatory cytokines and receptor activator of nuclear factor kappa B ligand (RANKL), a cell surface protein present in Th17 cells and osteoblasts. Osteoclast...
cartilage and dentin. Receptive activator of nuclear factor kappa-B ligand (RANKL), also called osteoclast differentiation factor (ODF) and osteoprotegerin...
decoy receptor and captures some RANKL before it can activate the osteoclasts through RANK. In other words, when RANKL binds to OPG, no response occurs...
rescue-phenotype studies, RANKL is shown to be a receptor activator of NF-κB ligand and play a role in differentiation of M cells. RANKL is expressed throughout...
Denosumab, a monoclonal antibody treatment RANKl inhibitor that targets the osteocyte apoptosis regulatory RANKL gene, is also prescribed to prevent bone...
conference on Computer and communications security, pp. 317–329. Wolfgang Rankl, Wolfgang Effing, Smart Card Handbook (2004) T. Welz: Smart cards as methods...
fibroblast-like synoviocytes, in the joint space. By signalling through RANKL and RANK, they eventually trigger osteoclast production, which degrades...
The Lost People (1949) as Guest (uncredited) Golden Salamander (1950) as Rankl Night and the City (1950) as Kristo State Secret (1950) as Karl Theodor...
Osteoprotegerin (OPG) binds RANKL before it has an opportunity to bind to RANK, and hence suppresses its ability to increase bone resorption. RANKL, RANK, and OPG...
overexpression of receptor activator for nuclear factor κ B ligand (RANKL) by bone marrow stroma. RANKL activates osteoclasts, which resorb bone. The resultant bone...
type of bone cells referred to as osteoblasts, causing them to release RANKL, which in turn activates osteoclasts. Calcitriol acts in concert with parathyroid...
downstream mediator of progesterone-induced lobuloalveolar maturation. RANKL knockout mice show an almost identical mammary phenotype to PR knockout...
London. Archived from the original on 6 July 2017. Retrieved 18 July 2014. Rankl, W.; W. Effing (1997). Smart Card Handbook. John Wiley & Sons. ISBN 0-471-96720-3...
osteoblasts and thereby indirectly stimulating osteoclasts (through RANK/RANKL mechanism) to break down bone and release calcium. PTH increases gastrointestinal...
Global Information
