Structure of the 4th LIM domain of Pinch protein. Zinc atoms are shown in grey
Identifiers
Symbol
LIM
Pfam
PF00412
InterPro
IPR001781
PROSITE
PDOC50178
SCOP2
1ctl / SCOPe / SUPFAM
CDD
cd08368
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
PDB
1ctlA:11–67
LIM domains are protein structural domains, composed of two contiguous zinc fingers, separated by a two-amino acid residue hydrophobic linker.[1] The domain name is an acronym of the three genes in which it was first identified (LIN-11, Isl-1 and MEC-3).[2] LIM is a protein interaction domain that is involved in binding to many structurally and functionally diverse partners.[1] The LIM domain appeared in eukaryotes sometime prior to the most recent common ancestor of plants, fungi, amoeba and animals.[3] In animal cells, LIM domain-containing proteins often shuttle between the cell nucleus where they can regulate gene expression, and the cytoplasm where they are usually associated with actin cytoskeletal structures involved in connecting cells together and to the surrounding matrix, such as stress fibers, focal adhesions and adherens junctions.[1]
LIM domain organization
^ abcKadrmas JL, Beckerle MC (November 2004). "The LIM domain: from the cytoskeleton to the nucleus". Nature Reviews. Molecular Cell Biology. 5 (11): 920–31. doi:10.1038/nrm1499. PMID 15520811. S2CID 6030950.
^Gill GN (December 1995). "The enigma of LIM domains". Structure. 3 (12): 1285–9. doi:10.1016/S0969-2126(01)00265-9. PMID 8747454.
^Koch BJ, Ryan JF, Baxevanis AD (March 2012). "The diversification of the LIM superclass at the base of the metazoa increased subcellular complexity and promoted multicellular specialization". PLOS ONE. 7 (3): e33261. Bibcode:2012PLoSO...733261K. doi:10.1371/journal.pone.0033261. PMC 3305314. PMID 22438907.
LIMdomains are protein structural domains, composed of two contiguous zinc fingers, separated by a two-amino acid residue hydrophobic linker. The domain...
Look up Lim or lim in Wiktionary, the free dictionary. Lim or LIM may refer to: Lim (Korean surname), a common Korean surname Lim (Chinese surname), Hokkien...
There are approximately 40 known eukaryotic LIM proteins, so named for the LIMdomains they contain. LIMdomains are highly conserved cysteine-rich structures...
Four and a half LIMdomains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene. LIM proteins contain a highly conserved...
LIMdomain only 2 (rhombotin-like 1), also known as LMO2, RBTNL1, RBTN2, RHOM2, LIMDomain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is...
LIMdomain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene. There are approximately 40 known eukaryotic LIM proteins, so named for the...
large protein family, members of which carry the LIMdomain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional...
LIM homeobox 1 is a protein that in humans is encoded by the LHX1 gene. This gene encodes a member of a large protein family which contains the LIM domain...
LIMdomain binding 3 (LDB3), also known as Z-band alternatively spliced PDZ-motif (ZASP), is a protein which in humans is encoded by the LDB3 gene. ZASP...
something that is mysterious or puzzling ENIGMA, a class of gene in the LIMdomain Enigma (company), a New York–based data-technology startup Enigma machine...
characteristic domain was first identified) encode two 60 amino acid cysteine and histidine-rich LIMdomains and a homeodomain. The LIMdomains function in...
homology (CH) domain, a PDZ domain, and a LIMdomain. An F-box (FBX) domain is present in alternative splice variants. Members of the LIM protein family...
LIMdomain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene. LDB1 has been shown to interact with other proteins such as LMO4...
frequency-domain behaviour of F ( s ) {\displaystyle F(s)} to calculate lim t → ∞ f ( t ) {\displaystyle \lim _{t\to \infty }f(t)} (or lim k → ∞ f [ k...
LIMdomain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene. LIMdomain only 4 is a cysteine-rich, two LIMdomain-containing...
PDZ and LIMdomain protein 7 is a protein that in humans is encoded by the PDLIM7 gene. The protein encoded by this gene is representative of a family...
LIMdomain-binding protein 2 is a protein that in humans is encoded by the LDB2 gene. LIMdomainLIMdomain-binding protein family GRCh38: Ensembl release...
PDZ and LIMdomain protein 1 is a protein that in humans is encoded by the PDLIM1 gene. PDLIM1 has been shown to interact with: Actinin alpha 4, Actinin...
f(t)=O(e^{ct})} ) and lim t → 0 + f ( t ) {\displaystyle \lim _{t\to 0^{+}}f(t)} exists then the initial value theorem says lim t → 0 f ( t ) = lim s → ∞ s F (...
LIMdomain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene. There are approximately 40 known eukaryotic LIM proteins, so named for the...
PDZ and LIMdomain protein 4 is a protein that in humans is encoded by the PDLIM4 gene. GRCh38: Ensembl release 89: ENSG00000131435 – Ensembl, May 2017...
Actin-associated LIM protein (ALP), also known as PDZ and LIMdomain protein 3 is a protein that in humans is encoded by the PDLIM3 gene. ALP is highly...
This gene encodes a transcription factor containing two N-terminal LIMdomains and one C-terminal homeodomain. The encoded protein plays an important...
Microtubule-associated monoxygenase, calponin and LIMdomain containing 3, also known as MICAL3, is a human gene. Along with two other Rab proteins, Rab6...
LIMdomain-containing protein 1 is a protein that in humans is encoded by the LIMD1 gene. GRCh38: Ensembl release 89: ENSG00000144791 – Ensembl, May 2017...
member of a large protein family which contains the LIMdomain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional...
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