RNA polymerase II transcription regulatory region sequence-specific DNA binding
Cellular component
intracellular anatomical structure
nucleus
Biological process
animal organ morphogenesis
medial motor column neuron differentiation
negative regulation of apoptotic process
regulation of transcription, DNA-templated
motor neuron axon guidance
transcription, DNA-templated
placenta development
transcription by RNA polymerase II
positive regulation of transcription by RNA polymerase II
neuron differentiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
89884
16872
Ensembl
ENSG00000121454
ENSMUSG00000026468
UniProt
Q969G2
P53776
RefSeq (mRNA)
NM_033343
NM_010712
RefSeq (protein)
NP_203129
NP_034842
Location (UCSC)
Chr 1: 180.23 – 180.28 Mb
Chr 1: 155.57 – 155.63 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
LIM/homeobox protein Lhx4 is a protein that in humans is encoded by the LHX4 gene.[5][6][7]
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of the pituitary gland. Mutations in this gene are associated with syndromic short stature and pituitary and hindbrain defects. An alternative splice variant has been described but its biological nature has not been determined.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000121454 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026468 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Liu Y, Fan M, Yu S, Zhou Y, Wang J, Yuan J, Qiang B (Feb 2002). "cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4". Brain Res. 928 (1–2): 147–155. doi:10.1016/S0006-8993(01)03243-7. PMID 11844481. S2CID 44298466.
^Machinis K, Pantel J, Netchine I, Leger J, Camand OJ, Sobrier ML, Dastot-Le Moal F, Duquesnoy P, Abitbol M, Czernichow P, Amselem S (Oct 2001). "Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4". Am J Hum Genet. 69 (5): 961–968. doi:10.1086/323764. PMC 1274372. PMID 11567216.
LIM/homeobox protein Lhx4 is a protein that in humans is encoded by the LHX4 gene. This gene encodes a member of a large protein family which contains...
Pickardt's syndrome that is associated with certain mutations (HESX1 or LHX4) is referred to as pituitary stalk interruption syndrome (PSIS). Typical...
Known motif – from protein with 100% identical DBD – in vitro [488] YAATHW LHX4 ENSG00000121454 Homeodomain Known motif – High-throughput in vitro [489]...
deficiencies (CPHD) in childhood. These are HESX1, PROP1, POU1F1, LHX3, LHX4, TBX19, SOX2 and SOX3. Each transcription factor acts in particular groups...
Matrix Full Name Position Start Position End Strand Matrix Score Function V$LHX4.01 LIM homeobox 4, Gsh4 58 80 (+) 0.849 Homeodomains play a role in vertebrate...
combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion". J. Clin. Endocrinol. Metab. 95 (8): 4043–7. doi:10.1210/jc.2010-0150...
combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development". Gene Expr. Patterns. 5 (2): 279–84...