PDLIM7 information

PDLIM7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q3G
Identifiers
Aliases	PDLIM7, LMP1, LMP3, PDZ and LIM domain 7
External IDs	OMIM: 605903; MGI: 1914649; HomoloGene: 3980; GeneCards: PDLIM7; OMA:PDLIM7 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 177,483,394 bp[1] End 177,497,606 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 55,643,608 bp[2] End 55,661,489 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of uterus right coronary artery ascending aorta Descending thoracic aorta popliteal artery tibial arteries left uterine tube gastric mucosa muscle layer of sigmoid colon left coronary artery Top expressed in muscle of thigh saccule external carotid artery granulocyte internal carotid artery otic placode tunica media of zone of aorta ascending aorta otic vesicle superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding actin binding muscle alpha-actinin binding Cellular component cytoplasm ruffle cytoskeleton nucleus stress fiber focal adhesion actin cytoskeleton cytosol Z disc filamentous actin Biological process multicellular organism development cell differentiation positive regulation of osteoblast differentiation receptor-mediated endocytosis actin cytoskeleton organization ossification axon guidance heart development muscle structure development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9260 67399 Ensembl ENSG00000196923 ENSMUSG00000021493 UniProt Q9NR12 Q3TJD7 RefSeq (mRNA) NM_005451 NM_203352 NM_203353 NM_213636 NM_001114087 NM_001114088 NM_026131 RefSeq (protein) NP_005442 NP_976227 NP_998801 NP_001107559 NP_001107560 NP_080407 Location (UCSC) Chr 5: 177.48 – 177.5 Mb Chr 13: 55.64 – 55.66 Mb PubMed search [3] [4]
Wikidata
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PDZ and LIM domain protein 7 is a protein that in humans is encoded by the PDLIM7 gene.^[5][6]

The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein–protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants.^[6]