ISL1 information

ISL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RGT, 4JCJ
Identifiers
Aliases	ISL1, ISLET1, Isl-1, ISL LIM homeobox 1
External IDs	OMIM: 600366; MGI: 101791; HomoloGene: 1661; GeneCards: ISL1; OMA:ISL1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	51,394,730 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	116,446,225 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; islet of Langerhans; ; human penis; ; urethra; ; pylorus; ; cardia; ; sperm; ; buccal mucosa cell; ; pancreatic ductal cell; ; gastric mucosa;
	Top expressed in
	superior cervical ganglion; ; genital tubercle; ; trigeminal ganglion; ; lumbar spinal ganglion; ; medial ganglionic eminence; ; islet of Langerhans; ; neural layer of retina; ; facial motor nucleus; ; vestibular sensory epithelium; ; median eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; bHLH transcription factor binding; protein binding; nuclear receptor binding; cis-regulatory region sequence-specific DNA binding; estrogen receptor binding; promoter-specific chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleoplasm; nucleus;
Biological process	negative regulation of neuron apoptotic process; peripheral nervous system neuron development; positive regulation of interleukin-1 alpha production; pituitary gland development; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; positive regulation of interleukin-12 production; axon regeneration; spinal cord motor neuron cell fate specification; trigeminal nerve development; neuron fate specification; outflow tract morphogenesis; positive regulation of interferon-gamma production; positive regulation of granulocyte colony-stimulating factor production; heart morphogenesis; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; positive regulation of angiogenesis; positive regulation of histone acetylation; outflow tract septum morphogenesis; endocardial cushion morphogenesis; ventricular cardiac muscle tissue morphogenesis; atrial septum morphogenesis; multicellular organism development; cardiac cell fate determination; regulation of secondary heart field cardioblast proliferation; cardiac muscle cell myoblast differentiation; cellular response to glucocorticoid stimulus; visceral motor neuron differentiation; mesenchymal cell differentiation; positive regulation of granulocyte macrophage colony-stimulating factor production; neural crest cell migration; neuron differentiation; positive regulation of cell population proliferation; positive regulation of interleukin-1 beta production; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; regulation of gene expression; pancreas development; positive regulation of macrophage colony-stimulating factor production; positive regulation of vascular endothelial growth factor production; negative regulation of protein homodimerization activity; positive regulation of DNA binding; peripheral nervous system neuron axonogenesis; spinal cord motor neuron differentiation; neuron fate commitment; secondary heart field specification; innervation; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of inflammatory response; cardiac right ventricle morphogenesis; negative regulation of canonical Wnt signaling pathway; positive regulation of insulin secretion; sensory system development; pharyngeal system development; retinal ganglion cell axon guidance; positive regulation of transcription by RNA polymerase II; positive regulation of cell differentiation; transcription, DNA-templated; cell differentiation; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of epithelial to mesenchymal transition; negative regulation of epithelial cell proliferation; heart development; axonogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3670
	16392
	ENSG00000016082
	ENSMUSG00000042258
	P61371
	P61372
	NM_002202
	NM_021459
	NP_002193
	NP_067434
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin gene enhancer protein ISL-1 is a protein that in humans is encoded by the ISL1 gene.^[5] ^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000016082 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042258 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tanizawa Y, Riggs AC, Dagogo-Jack S, Vaxillaire M, Froguel P, Liu L, et al. (July 1994). "Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism [corrected]". Diabetes. 43 (7): 935–941. doi:10.2337/diabetes.43.7.935. PMID 7912209.
^ "Entrez Gene: ISL1 ISL1 transcription factor, LIM/homeodomain, (islet-1)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000016082 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042258 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7912209-5] Tanizawa Y, Riggs AC, Dagogo-Jack S, Vaxillaire M, Froguel P, Liu L, et al. (July 1994). "Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism [corrected]". Diabetes. 43 (7): 935–941. doi:10.2337/diabetes.43.7.935. PMID 7912209.

[entrez-6] "Entrez Gene: ISL1 ISL1 transcription factor, LIM/homeodomain, (islet-1)".

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