LDB1 information

LDB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XJY, 2XJZ, 2YPA
Identifiers
Aliases	LDB1, CLIM2, NLI, CLIM-2, LDB-1, LIM domain binding 1
External IDs	OMIM: 603451 MGI: 894762 HomoloGene: 2891 GeneCards: LDB1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	102,120,368 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	46,033,653 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; ganglionic eminence; ; gastric mucosa; ; skin of abdomen; ; canal of the cervix; ; sural nerve; ; stromal cell of endometrium; ; anterior pituitary; ; left uterine tube; ; right lobe of thyroid gland;
	Top expressed in
	lip; ; thymus; ; yolk sac; ; superior frontal gyrus; ; corneal stroma; ; neural tube; ; maxillary prominence; ; ganglionic eminence; ; cerebellar cortex; ; lens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein homodimerization activity; transcription corepressor activity; LIM domain binding; chromatin binding; protein self-association; protein binding; cis-regulatory region sequence-specific DNA binding; enzyme binding; transcription coregulator activity;
Cellular component	transcription regulator complex; nucleus; cell leading edge; nucleoplasm; beta-catenin-TCF complex; protein-containing complex;
Biological process	hair follicle development; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; epithelial structure maintenance; regulation of transcription, DNA-templated; positive regulation of hemoglobin biosynthetic process; somatic stem cell population maintenance; regulation of transcription by RNA polymerase II; gastrulation with mouth forming second; cerebellar Purkinje cell differentiation; regulation of DNA-templated transcription, elongation; head development; histone H3-K4 acetylation; Wnt signaling pathway; transcription by RNA polymerase II; transcription, DNA-templated; cerebellum development; negative regulation of erythrocyte differentiation; multicellular organism development; neuron differentiation; anterior/posterior axis specification; cellular component assembly; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; positive regulation of cell adhesion; regulation of focal adhesion assembly; regulation of cell migration; regulation of kinase activity; regulation of hematopoietic stem cell differentiation; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	8861
	16825
	ENSG00000198728
	ENSMUSG00000025223
	Q86U70
	P70662
	NM_001113407; NM_003893; NM_001321612
	NM_001113408; NM_010697; NM_001360336
	NP_001106878; NP_001308541; NP_003884
	NP_001106879; NP_034827; NP_001347265
	Wikidata
View/Edit Human	View/Edit Mouse

LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198728 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025223 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamashita T, Agulnick AD, Copeland NG, Gilbert DJ, Jenkins NA, Westphal H (Apr 1998). "Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1". Genomics. 48 (1): 87–92. doi:10.1006/geno.1997.5163. PMID 9503020.
^ Semina EV, Altherr MR, Murray JC (Dec 1998). "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI". Mamm Genome. 9 (11): 921–4. doi:10.1007/s003359900899. PMID 9799849. S2CID 28813194.
^ "Entrez Gene: LDB1 LIM domain binding 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198728 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025223 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9503020-5] Yamashita T, Agulnick AD, Copeland NG, Gilbert DJ, Jenkins NA, Westphal H (Apr 1998). "Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1". Genomics. 48 (1): 87–92. doi:10.1006/geno.1997.5163. PMID 9503020.

[pmid9799849-6] Semina EV, Altherr MR, Murray JC (Dec 1998). "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI". Mamm Genome. 9 (11): 921–4. doi:10.1007/s003359900899. PMID 9799849. S2CID 28813194.

[entrez-7] "Entrez Gene: LDB1 LIM domain binding 1".

LDB1 information

and 16 Related for: LDB1 information

LDB1

RNF12

LMO4

LMO2

LHX6

RUNX1

LHX3

SSBP3

SSBP1

LMO1

Betasatellite

TCF3

TAL1

CBFA2T3

LDB2

FHL2