LIMK1 information

LIMK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3S95, 5L6W, 5HVK, 5HVJ
Identifiers
Aliases	LIMK1, LIMK, LIMK-1, LIM domain kinase 1
External IDs	OMIM: 601329; MGI: 104572; HomoloGene: 1738; GeneCards: LIMK1; OMA:LIMK1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	74,122,525 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	134,717,452 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; cingulate gyrus; ; prefrontal cortex; ; amygdala; ; Brodmann area 9; ; ganglionic eminence; ; monocyte; ; hypothalamus; ; nucleus accumbens; ; canal of the cervix;
	Top expressed in
	motor neuron; ; internal carotid artery; ; substantia nigra; ; external carotid artery; ; pontine nuclei; ; medial vestibular nucleus; ; anterior horn of spinal cord; ; supraoptic nucleus; ; trigeminal ganglion; ; fossa;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; heat shock protein binding; metal ion binding; kinase activity; protein binding; protein heterodimerization activity; ATP binding; protein kinase activity; protein serine/threonine kinase activity; signal transducer activity;
Cellular component	membrane; focal adhesion; cytoplasm; nucleus; Golgi apparatus; cytosol; nuclear speck; neuron projection; lamellipodium; cell projection;
Biological process	Fc-gamma receptor signaling pathway involved in phagocytosis; phosphorylation; nervous system development; negative regulation of ubiquitin-protein transferase activity; Rho protein signal transduction; positive regulation of actin filament bundle assembly; actin cytoskeleton organization; signal transduction; positive regulation of axon extension; protein phosphorylation; positive regulation of stress fiber assembly;
	Sources:Amigo / QuickGO
Orthologs
	3984
	16885
	ENSG00000106683
	ENSMUSG00000029674
	P53667
	P53668
	NM_016735; NM_001204426; NM_002314
	NM_010717; NM_001305875
	NP_001191355; NP_002305
	NP_001292804; NP_034847
	Wikidata
View/Edit Human	View/Edit Mouse

LIM domain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106683 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029674 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tassabehji M, Metcalfe K, Fergusson WD, Carette MJ, Dore JK, Donnai D, Read AP, Pröschel C, Gutowski NJ, Mao X, Sheer D (Aug 1996). "LIM-kinase deleted in Williams syndrome". Nat. Genet. 13 (3): 272–3. doi:10.1038/ng0796-272. PMID 8673124. S2CID 138698.
^ Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC (Jan 1997). "Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients". Genomics. 36 (2): 328–36. doi:10.1006/geno.1996.0469. PMID 8812460.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106683 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029674 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8673124-5] Tassabehji M, Metcalfe K, Fergusson WD, Carette MJ, Dore JK, Donnai D, Read AP, Pröschel C, Gutowski NJ, Mao X, Sheer D (Aug 1996). "LIM-kinase deleted in Williams syndrome". Nat. Genet. 13 (3): 272–3. doi:10.1038/ng0796-272. PMID 8673124. S2CID 138698.

[pmid8812460-6] Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC (Jan 1997). "Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients". Genomics. 36 (2): 328–36. doi:10.1006/geno.1996.0469. PMID 8812460.

LIMK1 information

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