LIMK2 information

LIMK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X6A, 4TPT
Identifiers
Aliases	LIMK2, LIM domain kinase 2
External IDs	OMIM: 601988; MGI: 1197517; HomoloGene: 55911; GeneCards: LIMK2; OMA:LIMK2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	31,280,080 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,359,189 bp
RNA expression pattern
	Top expressed in
	blood; ; skin of abdomen; ; hair follicle; ; right uterine tube; ; palpebral conjunctiva; ; minor salivary glands; ; left lobe of thyroid gland; ; rectum; ; right lobe of thyroid gland; ; placenta;
	Top expressed in
	lip; ; corneal stroma; ; superior frontal gyrus; ; esophagus; ; yolk sac; ; cerebellar cortex; ; blastocyst; ; neural tube; ; zone of skin; ; skin of back;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase activity; ATP binding; protein binding; protein heterodimerization activity; nucleotide binding; kinase activity; metal ion binding; protein kinase activity; transferase activity; signal transducer activity;
Cellular component	nucleus; cytoplasm; cis-Golgi network;
Biological process	protein phosphorylation; spermatogenesis; phosphorylation; intracellular signal transduction; head development; cornea development in camera-type eye; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	3985
	16886
	ENSG00000182541
	ENSMUSG00000020451
	P53671
	O54785
	NM_016733; NM_001031801; NM_005569
	NM_001034030; NM_010718; NM_173053; NM_001361623
	NP_001026971; NP_005560; NP_057952
NP_001029202; NP_034848; NP_774958; NP_001348552; NP_001389789;
	NP_001389790; NP_001389791; NP_001389792; NP_001389793
	Wikidata
View/Edit Human	View/Edit Mouse

LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182541 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020451 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Okano I, Hiraoka J, Otera H, Nunoue K, Ohashi K, Iwashita S, Hirai M, Mizuno K (Dec 1995). "Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs". The Journal of Biological Chemistry. 270 (52): 31321–30. doi:10.1074/jbc.270.52.31321. PMID 8537403.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ "Entrez Gene: LIMK2 LIM domain kinase 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182541 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020451 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8537403-5] Okano I, Hiraoka J, Otera H, Nunoue K, Ohashi K, Iwashita S, Hirai M, Mizuno K (Dec 1995). "Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs". The Journal of Biological Chemistry. 270 (52): 31321–30. doi:10.1074/jbc.270.52.31321. PMID 8537403.

[pmid10591208-6] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[entrez-7] "Entrez Gene: LIMK2 LIM domain kinase 2".

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