positive regulation of transcription by RNA polymerase II
ureter morphogenesis
endoderm development
mesendoderm development
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3975
16869
Ensembl
ENSG00000273706 ENSG00000274577
ENSMUSG00000018698
UniProt
P48742 Q58F18
P63006
RefSeq (mRNA)
NM_005568
NM_008498
RefSeq (protein)
NP_005559 NP_005559.2
NP_032524
Location (UCSC)
Chr 17: 36.94 – 36.94 Mb
Chr 11: 84.41 – 84.42 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
LIM homeobox 1 is a protein that in humans is encoded by the LHX1 gene.[5] This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for control of differentiation and development of neural and lymphoid cells. It is also key in development of renal and urogenital systems and is required for normal organogenesis.[6] A similar protein in mice is an essential regulator of the vertebrate head organizer.[5]
LIM homeobox 1 is a protein that in humans is encoded by the LHX1 gene. This gene encodes a member of a large protein family which contains the LIM domain...
specific TF according to literature or domain structure – No motif [485] LHX1 ENSG00000273706 Homeodomain Known motif – High-throughput in vitro [486]...
(Bouchard, 2002). Lhx1 expression also becomes more restricted to the intermediate mesoderm. Genetic analyses in animal studies show that Lhx1, Osr1 and Pax2/8...
proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript...
guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1". Neural Dev. 4: 21. doi:10.1186/1749-8104-4-21. PMC 2704203. PMID 19545367...
motor neurons during development. It has been found to bind LMO1, LMO2, Lhx1, Isl1, and Mec3. LMO2 is found to be localized in the nucleus, which is involved...
Halttunen M, Jokimaa V, Morin-Papunen L, Rosenberg C, Aittomäki K (2013). "TBX6, LHX1 and copy number variations in the complex genetics of Müllerian aplasia"...
Morin-Papunen, Laure; Rosenberg, Carla; Aittomäki, Kristiina (2013-08-16). "TBX6, LHX1 and copy number variations in the complex genetics of Müllerian aplasia"...
feature associated with Otx2 mutations. Otx2 also regulates two other genes, Lhx1 and Dkk1 that also play a role in head morphogenesis. Otx2 is required during...
Osr1 acts upstream of and causes expression of the transcription factors Lhx1, Pax2 and Wt1 which are involved in early urogenital development. In normal...